The JNK signalling transduction pathway in the brain

Xanthi Antoniou, Tiziana Borsello

Research output: Contribution to journalArticlepeer-review

Abstract

Among the numerous intracellular signalling pathways that control brain development and pathogenesis c-Jun N-terminal kinases have a leading role in the Central Nervous System. JNKs regulate a wide range of processes in brain development, plasticity, repair/regeneration, neuronal death and neuroinflammation. Indeed, accumulating evidence underline the potential of JNK targeted molecules towards the treatment of neurodegenerative disorders. The focus of the presenting review is to provide an overview of the reported data linking JNKs to brain function and dysfunction.

Original languageEnglish
Pages (from-to)2110-2120
Number of pages11
JournalFrontiers in Bioscience - Elite
Volume4 E
Issue number6
Publication statusPublished - Jan 1 2012

Keywords

  • AD
  • Brain development
  • Excitotoxicity
  • JNK
  • Neurodegeneration
  • Neuroinflammation
  • Pain
  • PD
  • Plasticity
  • Review
  • Scaffold protein
  • Stroke
  • Tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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