Abstract
Among the numerous intracellular signalling pathways that control brain development and pathogenesis c-Jun N-terminal kinases have a leading role in the Central Nervous System. JNKs regulate a wide range of processes in brain development, plasticity, repair/regeneration, neuronal death and neuroinflammation. Indeed, accumulating evidence underline the potential of JNK targeted molecules towards the treatment of neurodegenerative disorders. The focus of the presenting review is to provide an overview of the reported data linking JNKs to brain function and dysfunction.
| Original language | English |
|---|---|
| Pages (from-to) | 2110-2120 |
| Number of pages | 11 |
| Journal | Frontiers in Bioscience - Elite |
| Volume | 4 E |
| Issue number | 6 |
| Publication status | Published - Jan 1 2012 |
Keywords
- AD
- Brain development
- Excitotoxicity
- JNK
- Neurodegeneration
- Neuroinflammation
- Pain
- PD
- Plasticity
- Review
- Scaffold protein
- Stroke
- Tumor
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Medicine(all)