The junctional pattern of the human villous trophoblast: A freeze-fracture study

Giuseppe de Virgiliis, Mario Sideri, Guido Fumagalli, Gianni Remotti

Research output: Contribution to journalArticlepeer-review


This investigation of the junctional pattern of the human trophoblastic epithelium was carried out on the fractured faces of (a) the syncytial plasma membrane bathed by the maternal blood (S-PMm); (b) by syncytial plasma membrane in contact with either the cytotrophoblast or the trophoblastic basement membrane (S-PMf), and (c) the cytotrophoblastic plasma mebrane (C-PM). The most relevant findings were tight junctions on the SPMm. and the intertrophoblastic junctional pattern, not realizing a tight subcompartmentalization between syncytium and cytotrophoblast. The following aspects were discussed: The SPMf represents the last membrane barrier before the fetal capillary, and the function of the cytotrophoblast seems to be limited to the modulation of syncytial activity.

Original languageEnglish
Pages (from-to)263-272
Number of pages10
JournalGynecologic and Obstetric Investigation
Issue number4
Publication statusPublished - 1982


  • Freeze fracture
  • Junctions
  • Placenta

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


Dive into the research topics of 'The junctional pattern of the human villous trophoblast: A freeze-fracture study'. Together they form a unique fingerprint.

Cite this