The karyotype in secondary hematologic disorders after treatment for Hodgkin's disease. A study of 19 patients

Alessandra Iurlo, Cristina Mecucci, Angeline Van Orshoven, Jean Louis Michaux, Marc Boogaerts, Herman Van Den Berghe

Research output: Contribution to journalArticle

Abstract

In 19 cases of secondary hematologic disorders in patients previously treated for Hodgkin's disease, chromosome aberrations were analyzed in relation to the type of previous chemo- and/or radiotherapy, age of the patients, histopathologic features of the Hodgkin's disease at diagnosis, time interval between the treatment and the occurrence of the secondary disorder, and survival. The karyotype was of significant prognostic value when three cytogenetic groups were considered: patients with normal karyotypes; patients with aberrations of chromosome 7 as the sole anomaly; and patients with complex rearrangements and translocations. The last group showed the lowest rate of survival. Bone marrow transplantation was successful in two patients with a normal karyotype.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume36
Issue number2
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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