The KIND module: A putative signalling domain evolved from the C lobe of the protein kinase fold

Francesca D. Ciccarelli, Peer Bork, Eugen Kerkhoff

Research output: Contribution to journalArticle

Abstract

A novel putative interaction domain - KIND (kinase non-catalytic C-lobe domain) - has been identified as being similar to the C-terminal protein kinase catalytic fold (C lobe). Its presence at the N terminus of signalling proteins and the absence of the active-site residues in the catalytic and activation loops suggest that it folds independently and is likely to be non-catalytic. The occurrence of the novel domain only in metazoa implies that it has evolved from the catalytic protein kinase domain into an interaction domain possibly by keeping the substrate-binding features.

Original languageEnglish
Pages (from-to)349-352
Number of pages4
JournalTrends in Biochemical Sciences
Volume28
Issue number7
DOIs
Publication statusPublished - Jul 1 2003

ASJC Scopus subject areas

  • Biochemistry

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