The kinetics of reduction of minimal residual disease impacts on duration of response and survival of patients with acute myeloid leukemia

F. Buccisano, L. Maurillo, V. Gattei, G. Del Poeta, M. I. Del Principe, M. C. Cox, P. Panetta, M. Irno Consalvo, C. Mazzone, B. Neri, L. Ottaviani, D. Fraboni, A. Tamburini, F. Lo-Coco, S. Amadori, A. Venditti

Research output: Contribution to journalArticle

Abstract

We assessed by multiparametric flow cytometry the levels of minimal residual disease (MRD) in 100 adult patients with acute myelogenous leukemia (AML) achieving complete remission after intensive chemotherapy. The aim of the study was to determine the optimal threshold, in terms of residual leukemic cells, and the time point of choice, that is, post-induction (post-Ind) or post-consolidation (post-Cons), able to better predict outcome. By applying the maximally selected log-rank statistics, the threshold discriminating MRD- from MRD+ cases was set at 3.5 × 10-4 residual leukemic cells, a level that allowed the identification of distinct subgroups of patients, both at post-Ind and post-Cons time points. Post-Cons MRD- patients had a superior outcome in terms of relapse rate, overall survival (OS) and relapse-free survival (RFS) (P-4 is valid in discriminating risk categories in adult AML and (2) post-Cons MRD assessment is critical to predict disease outcome.

Original languageEnglish
Pages (from-to)1783-1789
Number of pages7
JournalLeukemia
Volume20
Issue number10
DOIs
Publication statusPublished - Oct 2006

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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    Buccisano, F., Maurillo, L., Gattei, V., Del Poeta, G., Del Principe, M. I., Cox, M. C., Panetta, P., Consalvo, M. I., Mazzone, C., Neri, B., Ottaviani, L., Fraboni, D., Tamburini, A., Lo-Coco, F., Amadori, S., & Venditti, A. (2006). The kinetics of reduction of minimal residual disease impacts on duration of response and survival of patients with acute myeloid leukemia. Leukemia, 20(10), 1783-1789. https://doi.org/10.1038/sj.leu.2404313