The kinetochore: From molecular discoveries to cancer therapy

Peter De Wulf; William C. Earnshaw

doi:10.1007/978-0-387-69076-6

The kinetochore: From molecular discoveries to cancer therapy

Peter De Wulf, William C. Earnshaw

Istituto Europeo di Oncologia

Research output: Book/Report › Book

Abstract

Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.

Original language	English
Publisher	Springer New York
Number of pages	509
ISBN (Print)	9780387690735
DOIs	https://doi.org/10.1007/978-0-387-69076-6
Publication status	Published - 2009

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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