Abstract
Measurements of the effect of NOAs are indicated in several situations: (a) patients with adverse events (i.e., thrombotic/hemorrhagic), particularly those who present with overdosage owing to excessive drug intake or decreased clearance; (b) patients undergoing surgical procedures for ensuring that no residual drug remains in the circulation; (c) patients requiring anticoagulation reversal because of life-threatening hemorrhage; (d) patients with renal insufficiency, who are likely to accumulate the drug in the circulation; (e) patients with liver failure, because NOAs are metabolized by the liver; (f) patients taking other drugs that might increase/decrease the effects of NOAs via drug- drug interactions. The choice of tests is based on such characteristics as availability, linearity of the dose- response curve, standardization, and responsiveness to increasing drug dosage. Practitioners need to be aware that NOAs can interfere with the measurement of common hemostasis parameters.
Original language | English |
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Pages (from-to) | 353-362 |
Number of pages | 10 |
Journal | Clinical Chemistry |
Volume | 59 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2013 |
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical