The length of SNCA Rep1 microsatellite may influence cognitive evolution in Parkinson's disease

Lucia Corrado, Fabiola D. De Marchi, Sara Tunesi, Gaia Donata Oggioni, Miryam Carecchio, Luca Magistrelli, Silvana Tesei, Giulio Riboldazzi, Alessio Di Fonzo, Clarissa Locci, Ilaria Trezzi, Roberta Zangaglia, Cristina Cereda, Sandra D'Alfonso, Corrado Magnani, Giacomo P. Comi, Giorgio Bono, Claudio Pacchetti, Roberto Cantello, Stefano GoldwurmCristoforo Comi

Research output: Contribution to journalArticle

Abstract

Background: Alpha-synuclein is a constituent of Lewy bodies and mutations of its gene cause familial Parkinson's disease (PD). A previous study showed that a variant of the alpha-synuclein gene (SNCA), namely the 263 bp allele of Rep1 was associated with faster motor progression in PD. On the contrary, a recent report failed to detect a detrimental effect of Rep1 263 on both motor and cognitive outcomes in PD. Aim of this study was to evaluate the influence of the Rep1 variants on disease progression in PD patients. Methods: We recruited and genotyped for SNCA Rep1 426 PD patients with age at onset ≥40 years and disease duration ≥4 years. We then analyzed frequency and time of occurrence of wearing-off, dyskinesia, freezing of gait, visual hallucinations, and dementia using a multivariate Cox's proportional hazards regression model. Results: SNCA Rep1 263 carriers showed significantly increased risk of both dementia (HR = 3.03) and visual hallucinations (HR = 2.69) compared to 263 non-carriers. Risk of motor complications did not differ in the two groups. Conclusion: SNCA Rep1 263 allele is associated with a worse cognitive outcome in PD.

Original languageEnglish
Article number213
JournalFrontiers in Neurology
Volume9
Issue numberMAR
DOIs
Publication statusPublished - Mar 29 2018

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Microsatellite Repeats
Parkinson Disease
alpha-Synuclein
Hallucinations
Dementia
Alleles
Lewy Bodies
Dyskinesias
Gait
Age of Onset
Proportional Hazards Models
Freezing
Genes
Disease Progression
Mutation

Keywords

  • Dementia
  • Disease progression
  • Genetic markers
  • Hallucinations
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Corrado, L., De Marchi, F. D., Tunesi, S., Oggioni, G. D., Carecchio, M., Magistrelli, L., ... Comi, C. (2018). The length of SNCA Rep1 microsatellite may influence cognitive evolution in Parkinson's disease. Frontiers in Neurology, 9(MAR), [213]. https://doi.org/10.3389/fneur.2018.00213

The length of SNCA Rep1 microsatellite may influence cognitive evolution in Parkinson's disease. / Corrado, Lucia; De Marchi, Fabiola D.; Tunesi, Sara; Oggioni, Gaia Donata; Carecchio, Miryam; Magistrelli, Luca; Tesei, Silvana; Riboldazzi, Giulio; Fonzo, Alessio Di; Locci, Clarissa; Trezzi, Ilaria; Zangaglia, Roberta; Cereda, Cristina; D'Alfonso, Sandra; Magnani, Corrado; Comi, Giacomo P.; Bono, Giorgio; Pacchetti, Claudio; Cantello, Roberto; Goldwurm, Stefano; Comi, Cristoforo.

In: Frontiers in Neurology, Vol. 9, No. MAR, 213, 29.03.2018.

Research output: Contribution to journalArticle

Corrado, L, De Marchi, FD, Tunesi, S, Oggioni, GD, Carecchio, M, Magistrelli, L, Tesei, S, Riboldazzi, G, Fonzo, AD, Locci, C, Trezzi, I, Zangaglia, R, Cereda, C, D'Alfonso, S, Magnani, C, Comi, GP, Bono, G, Pacchetti, C, Cantello, R, Goldwurm, S & Comi, C 2018, 'The length of SNCA Rep1 microsatellite may influence cognitive evolution in Parkinson's disease', Frontiers in Neurology, vol. 9, no. MAR, 213. https://doi.org/10.3389/fneur.2018.00213
Corrado L, De Marchi FD, Tunesi S, Oggioni GD, Carecchio M, Magistrelli L et al. The length of SNCA Rep1 microsatellite may influence cognitive evolution in Parkinson's disease. Frontiers in Neurology. 2018 Mar 29;9(MAR). 213. https://doi.org/10.3389/fneur.2018.00213
Corrado, Lucia ; De Marchi, Fabiola D. ; Tunesi, Sara ; Oggioni, Gaia Donata ; Carecchio, Miryam ; Magistrelli, Luca ; Tesei, Silvana ; Riboldazzi, Giulio ; Fonzo, Alessio Di ; Locci, Clarissa ; Trezzi, Ilaria ; Zangaglia, Roberta ; Cereda, Cristina ; D'Alfonso, Sandra ; Magnani, Corrado ; Comi, Giacomo P. ; Bono, Giorgio ; Pacchetti, Claudio ; Cantello, Roberto ; Goldwurm, Stefano ; Comi, Cristoforo. / The length of SNCA Rep1 microsatellite may influence cognitive evolution in Parkinson's disease. In: Frontiers in Neurology. 2018 ; Vol. 9, No. MAR.
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AU - Carecchio, Miryam

AU - Magistrelli, Luca

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