The leucocyte antigenic system HL A as a possible genetic marker of schizophrenia

This investigation has been performed on 53 unrelated schizophrenic patients, of whom 30 were female and 23 male. HL-A10 and HL-A13 have a lower but not significantly different frequency in schizophrenic patients and in control subjects. The essential phenomenological unhomogeneity of the schizophrenic population has induced the authors to group their patients in more homogeneous groups according to the classic nosographic criteria. HL-A frequencies in 28 hebephrenic and 20 paranoid patients are compared in a table. Catatonic patients were too few (5 subjects only) to be included in this comparison. Hebephrenic patients show a significantly higher frequency of HL-A1 (x² = 4.29; P<0.05). In paranoid patients HL-A9 and HL-A5 are increased, whereas W15 and W27 are decreased. In any case, however, significance is not reached.