Abstract
CD36, a scavenger receptor of class B (SR-B), helps mediate microglial and macrophage response to β-amyloid fibrils (βA), and seems to play a key role in the proinflammatory events associated with Alzheimer disease (AD) in many tissues. Peripheral leukocytes express many molecules and multiple receptors which undergo the same regulatory mechanisms as those operative in the brain. Thus, these cells, easily obtainable through peripheral blood sampling, may be used as a tool to investigate changes occurring in inaccessible brain areas. Based on these premises, we investigated the leukocyte expression of CD36 in 70 AD patients and in 30 subjects with mild cognitive impairment (MCI). Results were compared to those of 20 young and 40 age-matched control subjects. Leukocyte expression of CD36 was significantly reduced versus controls in both AD and MCI patients, while in young and old controls there were no age-related changes. Although preliminary, these data indicate that the reduction of CD36 expression in leukocytes is a disease-related phenomenon, occurring since the early stages of AD (MCI). Irrespective of the mechanism(s) underlying such changes, assessment of leukocyte CD36 expression might represent an useful tool to support the diagnosis of AD and to screen MCI patients candidates to develop the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 515-518 |
| Number of pages | 4 |
| Journal | Neurobiology of Aging |
| Volume | 28 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2007 |
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Keywords
- Alzheimer's disease
- CD36
- Leukocytes
- MCI
ASJC Scopus subject areas
- Clinical Neurology
- Biological Psychiatry
- Developmental Neuroscience
- Neurology
- Psychology(all)
Cite this
The leukocyte expression of CD36 is low in patients with Alzheimer's disease and mild cognitive impairment. / Giunta, M.; Rigamonti, A. E.; Scarpini, E.; Galimberti, D.; Bonomo, S. M.; Venturelli, E.; Müller, E. E.; Cella, S. G.
In: Neurobiology of Aging, Vol. 28, No. 4, 04.2007, p. 515-518.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The leukocyte expression of CD36 is low in patients with Alzheimer's disease and mild cognitive impairment
AU - Giunta, M.
AU - Rigamonti, A. E.
AU - Scarpini, E.
AU - Galimberti, D.
AU - Bonomo, S. M.
AU - Venturelli, E.
AU - Müller, E. E.
AU - Cella, S. G.
PY - 2007/4
Y1 - 2007/4
N2 - CD36, a scavenger receptor of class B (SR-B), helps mediate microglial and macrophage response to β-amyloid fibrils (βA), and seems to play a key role in the proinflammatory events associated with Alzheimer disease (AD) in many tissues. Peripheral leukocytes express many molecules and multiple receptors which undergo the same regulatory mechanisms as those operative in the brain. Thus, these cells, easily obtainable through peripheral blood sampling, may be used as a tool to investigate changes occurring in inaccessible brain areas. Based on these premises, we investigated the leukocyte expression of CD36 in 70 AD patients and in 30 subjects with mild cognitive impairment (MCI). Results were compared to those of 20 young and 40 age-matched control subjects. Leukocyte expression of CD36 was significantly reduced versus controls in both AD and MCI patients, while in young and old controls there were no age-related changes. Although preliminary, these data indicate that the reduction of CD36 expression in leukocytes is a disease-related phenomenon, occurring since the early stages of AD (MCI). Irrespective of the mechanism(s) underlying such changes, assessment of leukocyte CD36 expression might represent an useful tool to support the diagnosis of AD and to screen MCI patients candidates to develop the disease.
AB - CD36, a scavenger receptor of class B (SR-B), helps mediate microglial and macrophage response to β-amyloid fibrils (βA), and seems to play a key role in the proinflammatory events associated with Alzheimer disease (AD) in many tissues. Peripheral leukocytes express many molecules and multiple receptors which undergo the same regulatory mechanisms as those operative in the brain. Thus, these cells, easily obtainable through peripheral blood sampling, may be used as a tool to investigate changes occurring in inaccessible brain areas. Based on these premises, we investigated the leukocyte expression of CD36 in 70 AD patients and in 30 subjects with mild cognitive impairment (MCI). Results were compared to those of 20 young and 40 age-matched control subjects. Leukocyte expression of CD36 was significantly reduced versus controls in both AD and MCI patients, while in young and old controls there were no age-related changes. Although preliminary, these data indicate that the reduction of CD36 expression in leukocytes is a disease-related phenomenon, occurring since the early stages of AD (MCI). Irrespective of the mechanism(s) underlying such changes, assessment of leukocyte CD36 expression might represent an useful tool to support the diagnosis of AD and to screen MCI patients candidates to develop the disease.
KW - Alzheimer's disease
KW - CD36
KW - Leukocytes
KW - MCI
UR - http://www.scopus.com/inward/record.url?scp=33847204688&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847204688&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2006.02.002
DO - 10.1016/j.neurobiolaging.2006.02.002
M3 - Article
C2 - 16563568
AN - SCOPUS:33847204688
VL - 28
SP - 515
EP - 518
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 4
ER -