The level of cortical afferent inhibition in acute stroke correlates with long-term functional recovery in humans

Vincenzo Di Lazzaro, Paolo Profice, Fabio Pilato, Fioravante Capone, Federico Ranieri, Lucia Florio, Cesare Colosimo, Emanuele Pravatà, Patrizio Pasqualetti, Michele Dileone

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Purpose-: Using transcranial magnetic stimulation, we investigated short-interval intracortical inhibition and short-latency afferent inhibition in acute ischemic stroke. Methods-: We evaluated short-interval intracortical inhibition and short-latency afferent inhibition in the affected hemisphere and unaffected hemisphere in 16 patients and correlated electrophysiological parameters with outcome at 6 months. Results-: Affected hemisphere short-latency afferent inhibition was significantly reduced in patients, and short-latency afferent inhibition level correlated with functional outcome. Conclusions-: Reduced afferent inhibition in acute stroke correlates with long-term recovery.

Original languageEnglish
Pages (from-to)250-252
Number of pages3
JournalStroke
Volume43
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • GABA
  • transcranial magnetic stimulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

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