The level of spinal cord involvement influences the pattern of movement-associated cortical recruitment in patients with isolated myelitis

Research output: Contribution to journalArticle

Abstract

Using fMRI, an increased recruitment of the ipsilateral primary sensorimotor cortex (SMC), supplementary motor area, and middle frontal gyrus has been detected in patients with cervical cord myelitis of possible demyelinating origin. The aim of this study was to evaluate, using fMRI, whether the level of cord involvement influences cortical reorganization by comparing patients with isolated myelitis of the cervical and the dorsal portions of the cord, and to investigate whether the extent of cortical reorganization is associated with the extent of cervical cord pathology measured using magnetization transfer (MT) MRI. We studied 24 right-handed patients (14 with a previous involvement of the cervical cord and 10 with an involvement of the dorsal cord) in a chronic and clinically stable phase following an isolated myelitis of possible demyelinating origin and 15 sex- and age-matched healthy controls. During a single session, we obtained fMRI during repetitive flexion-extension of the last four fingers of the right and left hands and cervical cord MT MRI. Average cord MTR was lower in patients with cervical (P 

Original languageEnglish
Pages (from-to)879-884
Number of pages6
JournalNeuroImage
Volume30
Issue number3
DOIs
Publication statusPublished - Apr 15 2006

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

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