The levels of transforming growth factor-β1 are increased in the serum of patients with psoriasis and correlate with disease severity

Claudio Bonifati, Massimo Carducci, Anna Mussi, Antonio Pittarello, Giovanna D'Agosto, Marcello Fazio, Franco Ameglio

Research output: Contribution to journalArticle

Abstract

The serum transforming growth factor-β1 (TGF-β1), the soluble intercellular adhesion molecule (sICAM-1), the soluble E-selectin (sE-selectin), the soluble L-selectin (sL-selectin) and the interleukin-1 receptor antagonist (IL-1Ra) levels were determined in 15 samples of psoriatic serum using commercially available ELISA kits. The median serum TGF-β1 levels were significantly increased as compared to the 21 healthy subjects and a significant correlation with the PASI scores was observed, suggesting an involvement of this cytokine in the pathogenic mechanisms of plaque-type psoriasis. Despite 4 weeks of effective therapy and a subsequent drop in the PASI scores, no significant TGF-β1 modifications were observed in the treated patients, suggesting a persistence of the raised levels of this molecule in the blood. This has been previously shown for other molecules, suggesting a time dissociation between TGF-β1 metabolism and recovery. Significant correlations were found with the serum TGF-β1, sICAM-1, sE-selectin, sL-selectin and IL-1Ra levels, whose interrelationships with TGF-β1 have been previously reported in the literature. This indirectly suggests that the amounts of serum TGF-β1, although altered, are biologically coordinated and may be active, exerting functions known to be TGF-β1-dependent such as monocyte stimulation, neoangionesis and fibroblast activation.

Original languageEnglish
Pages (from-to)486-490
Number of pages5
JournalEuropean Journal of Dermatology
Volume6
Issue number7
Publication statusPublished - 1996

Keywords

  • IL-1Ra
  • PASI
  • Psoriasis
  • sE-selectin
  • Serum
  • sICAM-1
  • sL-selectin
  • TGF-β1

ASJC Scopus subject areas

  • Dermatology

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