The levodopa wearing-off phenomenon in Parkinson's disease: Pharmacokinetic considerations

Research output: Contribution to journalArticlepeer-review

Abstract

Levodopa is the most efficacious treatment in the management of Parkinson's disease. Unfortunately, chronic use of traditional levodopa/dopa decarboxylase inhibitor formulations is associated with the development of complications, such as wearing-off and dyskinesia. In an attempt to avoid these complications, some physicians delay the introduction of levodopa or employ levodopa-sparing strategies; however, these strategies are frequently suboptimal for patients. As most patients require the superior efficacy of levodopa during the course of their disease, an appreciation of the changing response to levodopa over time and an understanding of the pharmacokinetic principles underlying the development of complications such as wearing-off is essential in the long-term management of the patient.

Original languageEnglish
Pages (from-to)1399-1407
Number of pages9
JournalExpert Opinion on Pharmacotherapy
Volume7
Issue number10
DOIs
Publication statusPublished - Jul 2006

Keywords

  • Entacapone
  • Levodopa
  • Motor fluctuations
  • Parkinson's disease
  • Wearing-off

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology

Fingerprint Dive into the research topics of 'The levodopa wearing-off phenomenon in Parkinson's disease: Pharmacokinetic considerations'. Together they form a unique fingerprint.

Cite this