The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases

LIFE PERSUADED Project Group

Research output: Contribution to journalArticle

Abstract

Phthalates and bisphenol A (BPA), plasticizers used in several products of daily life, are considered as endocrine disrupters, therefore children exposure is particularly relevant. The LIFE PERSUADED project aims to define the following: (a) the evaluation of internal levels of DEHP's metabolites and BPA in Italian children and their mothers, (b) the association of the exposure with puberty development and obesity diseases, and (c) the effects of exposure in juvenile in vivo model. The cross-sectional study has involved 2160 mother-child pairs, including males and females, children and adolescents, from urban and rural areas of North, Center, and South Italy. A structured questionnaire and a food diary are designed to evaluate the association between lifestyle variables potentially related to DEHP/BPA exposure and internal levels, through univariate and multivariate analyses. Two pilot case-control studies are carried out on idiopathic premature thelarche and precocious puberty (30 girls each group, aged 2-7 years) and idiopathic obesity (30 boys and 30 girls, aged 6-10 years), matched to healthy controls. BPA and DEHP's metabolites are analyzed in urine samples from all recruited subjects. Clinical and toxicological biomarkers are evaluated in serum of case-control subjects. Moreover, the toxicity study is carried out in a juvenile rodent model exposed to mixtures of BPA and DEHP at dose levels recorded in children population. The scientific results of LIFE PERSUADED will contribute to risk assessment of BPA and DEHP.

Original languageEnglish
Pages (from-to)25618-25625
Number of pages8
JournalEnvironmental Science and Pollution Research
Volume25
Issue number25
DOIs
Publication statusPublished - Sep 2018

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Diethylhexyl Phthalate
Environmental Monitoring
phthalate
biomonitoring
Mothers
Metabolites
Endocrine disrupters
Association reactions
obesity
Plasticizers
Biomarkers
metabolite
Risk assessment
Toxicity
Obesity
endocrine disruptor
Precocious Puberty
Diet Records
lifestyle
urine

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The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases. / LIFE PERSUADED Project Group.

In: Environmental Science and Pollution Research, Vol. 25, No. 25, 09.2018, p. 25618-25625.

Research output: Contribution to journalArticle

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abstract = "Phthalates and bisphenol A (BPA), plasticizers used in several products of daily life, are considered as endocrine disrupters, therefore children exposure is particularly relevant. The LIFE PERSUADED project aims to define the following: (a) the evaluation of internal levels of DEHP's metabolites and BPA in Italian children and their mothers, (b) the association of the exposure with puberty development and obesity diseases, and (c) the effects of exposure in juvenile in vivo model. The cross-sectional study has involved 2160 mother-child pairs, including males and females, children and adolescents, from urban and rural areas of North, Center, and South Italy. A structured questionnaire and a food diary are designed to evaluate the association between lifestyle variables potentially related to DEHP/BPA exposure and internal levels, through univariate and multivariate analyses. Two pilot case-control studies are carried out on idiopathic premature thelarche and precocious puberty (30 girls each group, aged 2-7 years) and idiopathic obesity (30 boys and 30 girls, aged 6-10 years), matched to healthy controls. BPA and DEHP's metabolites are analyzed in urine samples from all recruited subjects. Clinical and toxicological biomarkers are evaluated in serum of case-control subjects. Moreover, the toxicity study is carried out in a juvenile rodent model exposed to mixtures of BPA and DEHP at dose levels recorded in children population. The scientific results of LIFE PERSUADED will contribute to risk assessment of BPA and DEHP.",
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AU - LIFE PERSUADED Project Group

AU - La Rocca, Cinzia

AU - Maranghi, Francesca

AU - Tait, Sabrina

AU - Tassinari, Roberta

AU - Baldi, Francesca

AU - Bottaro, Giorgia

AU - Buzzigoli, Emma

AU - Carli, Fabrizia

AU - Cianfarani, Stefano

AU - Conte, Raffaele

AU - Deodati, Annalisa

AU - Gastaldelli, Amalia

AU - Pala, Anna Paola

AU - Raffaelli, Andrea

AU - Saponaro, Chiara

AU - Scirè, Giuseppe

AU - Spadoni, Gian Luigi

AU - Busani, Luca

PY - 2018/9

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