Abstract
Objective: The criteria for defining subclinical hypercortisolism (SH) are debated and a real gold standard test or combination of tests is lacking. Recently, late-night salivary cortisol (MSC) has been described as a sensitive and easy-to-perform marker for diagnosing overt hypercortisolism. No data are available on the role of MSC in the diagnosis of SH. The aim of this study was to evaluate the sensitivity and specificity of MSC levels in the diagnosis of SH in patients with adrenal incidentalomas (AI). Methods: In 103 (females/males, 69/34) patients with AI, MSC levels were studied. One milligram overnight dexamethasone suppression test (DST), urinary-free cortisol (UFC), and ACTH plasma levels were also evaluated. Patients were defined as affected by SH if they showed two of the following criteria: DST>83 nmol/l, ACTH 193 nmol/24 h. Results: No difference in MSC levels in patients with SH (3.1±3.1 nmol/l) compared with patients without SH (2.2±2.8 nmol/l) was observed. In patients with SH, MSC levels were significantly correlated with DST (r=0.4, P
| Original language | English |
|---|---|
| Pages (from-to) | 87-92 |
| Number of pages | 6 |
| Journal | European Journal of Endocrinology |
| Volume | 160 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Medicine(all)
Cite this
The limited role of midnight salivary cortisol levels in the diagnosis of subclinical hypercortisolism in patients with adrenal incidentaloma. / Masserini, Benedetta; Morelli, Valentina; Bergamaschi, Silvia; Ermetici, Federica; Eller-Vainicher, Cristina; Barbieri, Anna Maria; Maffini, Maria Antonia; Scillitani, Alfredo; Ambrosi, Bruno; Beck-Peccoz, Paolo; Chiodini, Iacopo.
In: European Journal of Endocrinology, Vol. 160, No. 1, 2009, p. 87-92.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The limited role of midnight salivary cortisol levels in the diagnosis of subclinical hypercortisolism in patients with adrenal incidentaloma
AU - Masserini, Benedetta
AU - Morelli, Valentina
AU - Bergamaschi, Silvia
AU - Ermetici, Federica
AU - Eller-Vainicher, Cristina
AU - Barbieri, Anna Maria
AU - Maffini, Maria Antonia
AU - Scillitani, Alfredo
AU - Ambrosi, Bruno
AU - Beck-Peccoz, Paolo
AU - Chiodini, Iacopo
PY - 2009
Y1 - 2009
N2 - Objective: The criteria for defining subclinical hypercortisolism (SH) are debated and a real gold standard test or combination of tests is lacking. Recently, late-night salivary cortisol (MSC) has been described as a sensitive and easy-to-perform marker for diagnosing overt hypercortisolism. No data are available on the role of MSC in the diagnosis of SH. The aim of this study was to evaluate the sensitivity and specificity of MSC levels in the diagnosis of SH in patients with adrenal incidentalomas (AI). Methods: In 103 (females/males, 69/34) patients with AI, MSC levels were studied. One milligram overnight dexamethasone suppression test (DST), urinary-free cortisol (UFC), and ACTH plasma levels were also evaluated. Patients were defined as affected by SH if they showed two of the following criteria: DST>83 nmol/l, ACTH 193 nmol/24 h. Results: No difference in MSC levels in patients with SH (3.1±3.1 nmol/l) compared with patients without SH (2.2±2.8 nmol/l) was observed. In patients with SH, MSC levels were significantly correlated with DST (r=0.4, P
AB - Objective: The criteria for defining subclinical hypercortisolism (SH) are debated and a real gold standard test or combination of tests is lacking. Recently, late-night salivary cortisol (MSC) has been described as a sensitive and easy-to-perform marker for diagnosing overt hypercortisolism. No data are available on the role of MSC in the diagnosis of SH. The aim of this study was to evaluate the sensitivity and specificity of MSC levels in the diagnosis of SH in patients with adrenal incidentalomas (AI). Methods: In 103 (females/males, 69/34) patients with AI, MSC levels were studied. One milligram overnight dexamethasone suppression test (DST), urinary-free cortisol (UFC), and ACTH plasma levels were also evaluated. Patients were defined as affected by SH if they showed two of the following criteria: DST>83 nmol/l, ACTH 193 nmol/24 h. Results: No difference in MSC levels in patients with SH (3.1±3.1 nmol/l) compared with patients without SH (2.2±2.8 nmol/l) was observed. In patients with SH, MSC levels were significantly correlated with DST (r=0.4, P
UR - http://www.scopus.com/inward/record.url?scp=58249090534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58249090534&partnerID=8YFLogxK
U2 - 10.1530/EJE-08-0485
DO - 10.1530/EJE-08-0485
M3 - Article
C2 - 18835977
AN - SCOPUS:58249090534
VL - 160
SP - 87
EP - 92
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 1
ER -