TY - JOUR
T1 - The Link Between Autonomic Nervous System and Rheumatoid Arthritis
T2 - From Bench to Bedside
AU - Ingegnoli, Francesca
AU - Buoli, Massimiliano
AU - Antonucci, Flavia
AU - Coletto, Lavinia Agra
AU - Esposito, Cecilia Maria
AU - Caporali, Roberto
N1 - Funding Information:
This research was supported by the grant Bando Straordinario per Progetti Interdipartimentali (project code 1079) from the Università degli Studibreak di Milano.
Publisher Copyright:
© Copyright © 2020 Ingegnoli, Buoli, Antonucci, Coletto, Esposito and Caporali.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12/7
Y1 - 2020/12/7
N2 - Neuronal stimulation is an emerging field of research focused on the management and treatment of various diseases through the reestablishment of physiological homeostasis. Electrical vagus nerve stimulation has recently been proposed as a revolutionary therapeutic option for rheumatoid arthritis (RA) in combination with or even as a replacement for conventional and biological drugs. In the past few years, disruption of the autonomic system has been linked to RA onset and activity. Novel research on the link between the autonomic nervous system and the immune system (immune-autonomics) has paved the way for the development of innovative RA management strategies. Clinical evidence supports this approach. Cardiovascular involvement, in terms of reduced baroreflex sensitivity and heart rate variability-derived indices, and mood disorders, common comorbidities in patients with RA, have been linked to autonomic nervous system dysfunction, which in turn is influenced by increased levels of circulating pro-inflammatory cytokines. This narrative review provides an overview of the autonomic nervous system and RA connection, discussing most of the common cardiac and mental health-related RA comorbidities and their potential relationships to systemic and joint inflammation.
AB - Neuronal stimulation is an emerging field of research focused on the management and treatment of various diseases through the reestablishment of physiological homeostasis. Electrical vagus nerve stimulation has recently been proposed as a revolutionary therapeutic option for rheumatoid arthritis (RA) in combination with or even as a replacement for conventional and biological drugs. In the past few years, disruption of the autonomic system has been linked to RA onset and activity. Novel research on the link between the autonomic nervous system and the immune system (immune-autonomics) has paved the way for the development of innovative RA management strategies. Clinical evidence supports this approach. Cardiovascular involvement, in terms of reduced baroreflex sensitivity and heart rate variability-derived indices, and mood disorders, common comorbidities in patients with RA, have been linked to autonomic nervous system dysfunction, which in turn is influenced by increased levels of circulating pro-inflammatory cytokines. This narrative review provides an overview of the autonomic nervous system and RA connection, discussing most of the common cardiac and mental health-related RA comorbidities and their potential relationships to systemic and joint inflammation.
KW - autonomic nervous system
KW - central nervous system
KW - depression
KW - mood disorder
KW - rheumatoid arthritis
KW - therapy
KW - vagus nerve
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U2 - 10.3389/fmed.2020.589079
DO - 10.3389/fmed.2020.589079
M3 - Review article
AN - SCOPUS:85098050608
VL - 7
JO - Frontiers in Medicine
JF - Frontiers in Medicine
SN - 2296-858X
M1 - 589079
ER -