Il fegato e la malattia celiaca

Translated title of the contribution: The liver and coeliac disease

Giuseppe Maggiore, Silvia Caprai, Marco Sciveres, Francesco Massei

Research output: Contribution to journalArticlepeer-review


A child with typical coeliac disease at the moment of diagnosis presents a significant increase in aminotransferase in 2/3 of cases. This figure rapidly drops in a gluten-free diet. The increase in aminotransferase is confirmed by a histological framework of non-progressive, moderate inflammatory lesions. This probably auto-immune "coeliac hepatitis" can, on the other hand, constitute the sole manifestation of coeliac disease: 10% of subjects with an unexplained increase in aminotransferase are in reality asymptomatic or oligosymptomatic coeliac disease subjects. Other forms, which are instead serious and progressive, of auto-immune hepatopathy are associated with coeliac disease, with a far lesser frequency but which is nevertheless significant: auto immune hepatitis, whether of type 1 of type 2, is 4 times greater in those with coeliac disease than in the general population; biliary cirrhosis is significantly associated with coeliac disease; the prevalence of this illness in those with coeliac disease is 20 times greater than in the general population.

Translated title of the contributionThe liver and coeliac disease
Original languageItalian
Pages (from-to)25-28+8
JournalMedico e Bambino
Issue number7 SUPPL.
Publication statusPublished - Sep 30 2002

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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