A child with typical coeliac disease at the moment of diagnosis presents a significant increase in aminotransferase in 2/3 of cases. This figure rapidly drops in a gluten-free diet. The increase in aminotransferase is confirmed by a histological framework of non-progressive, moderate inflammatory lesions. This probably auto-immune "coeliac hepatitis" can, on the other hand, constitute the sole manifestation of coeliac disease: 10% of subjects with an unexplained increase in aminotransferase are in reality asymptomatic or oligosymptomatic coeliac disease subjects. Other forms, which are instead serious and progressive, of auto-immune hepatopathy are associated with coeliac disease, with a far lesser frequency but which is nevertheless significant: auto immune hepatitis, whether of type 1 of type 2, is 4 times greater in those with coeliac disease than in the general population; biliary cirrhosis is significantly associated with coeliac disease; the prevalence of this illness in those with coeliac disease is 20 times greater than in the general population.
|Translated title of the contribution||The liver and coeliac disease|
|Journal||Medico e Bambino|
|Issue number||7 SUPPL.|
|Publication status||Published - Sep 30 2002|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health