Abstract
Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.
| Original language | English |
|---|---|
| Pages (from-to) | 99-106 |
| Number of pages | 8 |
| Journal | Journal of Neuroimmunology |
| Volume | 260 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2013 |
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Keywords
- Cancer-associated inflammation
- Glioma
- Immunohistochemistry
- Macrophage
- PTX3
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas. / Locatelli, Marco; Ferrero, Stefano; Martinelli Boneschi, Filippo; Boiocchi, Leonardo; Zavanone, Mario; Maria Gaini, Sergio; Bello, Lorenzo; Valentino, Sonia; Barbati, Elisa; Nebuloni, Manuela; Mantovani, Alberto; Garlanda, Cecilia.
In: Journal of Neuroimmunology, Vol. 260, No. 1-2, 2013, p. 99-106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas
AU - Locatelli, Marco
AU - Ferrero, Stefano
AU - Martinelli Boneschi, Filippo
AU - Boiocchi, Leonardo
AU - Zavanone, Mario
AU - Maria Gaini, Sergio
AU - Bello, Lorenzo
AU - Valentino, Sonia
AU - Barbati, Elisa
AU - Nebuloni, Manuela
AU - Mantovani, Alberto
AU - Garlanda, Cecilia
PY - 2013
Y1 - 2013
N2 - Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.
AB - Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.
KW - Cancer-associated inflammation
KW - Glioma
KW - Immunohistochemistry
KW - Macrophage
KW - PTX3
UR - http://www.scopus.com/inward/record.url?scp=84878658286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878658286&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2013.04.009
DO - 10.1016/j.jneuroim.2013.04.009
M3 - Article
VL - 260
SP - 99
EP - 106
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -