The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas

Marco Locatelli; Stefano Ferrero; Filippo Martinelli Boneschi; Leonardo Boiocchi; Mario Zavanone; Sergio Maria Gaini; Lorenzo Bello; Sonia Valentino; Elisa Barbati; Manuela Nebuloni; Alberto Mantovani; Cecilia Garlanda

doi:10.1016/j.jneuroim.2013.04.009

The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas

Marco Locatelli, Stefano Ferrero, Filippo Martinelli Boneschi, Leonardo Boiocchi, Mario Zavanone, Sergio Maria Gaini, Lorenzo Bello, Sonia Valentino, Elisa Barbati, Manuela Nebuloni, Alberto Mantovani, Cecilia Garlanda

Research output: Contribution to journal › Article › peer-review

Abstract

Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.

Original language	English
Pages (from-to)	99-106
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	260
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.04.009
Publication status	Published - 2013

Keywords

Cancer-associated inflammation
Glioma
Immunohistochemistry
Macrophage
PTX3

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

Access to Document

10.1016/j.jneuroim.2013.04.009

Cite this

Locatelli, M., Ferrero, S., Martinelli Boneschi, F., Boiocchi, L., Zavanone, M., Maria Gaini, S., Bello, L., Valentino, S., Barbati, E., Nebuloni, M., Mantovani, A., & Garlanda, C. (2013). The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas. Journal of Neuroimmunology, 260(1-2), 99-106. https://doi.org/10.1016/j.jneuroim.2013.04.009

The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas. / Locatelli, Marco; Ferrero, Stefano; Martinelli Boneschi, Filippo; Boiocchi, Leonardo; Zavanone, Mario; Maria Gaini, Sergio; Bello, Lorenzo ; Valentino, Sonia; Barbati, Elisa; Nebuloni, Manuela; Mantovani, Alberto ; Garlanda, Cecilia.

In: Journal of Neuroimmunology, Vol. 260, No. 1-2, 2013, p. 99-106.

Research output: Contribution to journal › Article › peer-review

Locatelli, M, Ferrero, S, Martinelli Boneschi, F, Boiocchi, L, Zavanone, M, Maria Gaini, S, Bello, L , Valentino, S, Barbati, E, Nebuloni, M, Mantovani, A & Garlanda, C 2013, 'The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas', Journal of Neuroimmunology, vol. 260, no. 1-2, pp. 99-106. https://doi.org/10.1016/j.jneuroim.2013.04.009

Locatelli, Marco ; Ferrero, Stefano ; Martinelli Boneschi, Filippo ; Boiocchi, Leonardo ; Zavanone, Mario ; Maria Gaini, Sergio ; Bello, Lorenzo ; Valentino, Sonia ; Barbati, Elisa ; Nebuloni, Manuela ; Mantovani, Alberto ; Garlanda, Cecilia. / The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas. In: Journal of Neuroimmunology. 2013 ; Vol. 260, No. 1-2. pp. 99-106.

@article{ef8672fb8b1547849b0aafc396f8b8e0,

title = "The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas",

abstract = "Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.",

keywords = "Cancer-associated inflammation, Glioma, Immunohistochemistry, Macrophage, PTX3",

author = "Marco Locatelli and Stefano Ferrero and {Martinelli Boneschi}, Filippo and Leonardo Boiocchi and Mario Zavanone and {Maria Gaini}, Sergio and Lorenzo Bello and Sonia Valentino and Elisa Barbati and Manuela Nebuloni and Alberto Mantovani and Cecilia Garlanda",

year = "2013",

doi = "10.1016/j.jneuroim.2013.04.009",

language = "English",

volume = "260",

pages = "99--106",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier Science B.V.",

number = "1-2",

}

TY - JOUR

T1 - The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas

AU - Locatelli, Marco

AU - Ferrero, Stefano

AU - Martinelli Boneschi, Filippo

AU - Boiocchi, Leonardo

AU - Zavanone, Mario

AU - Maria Gaini, Sergio

AU - Bello, Lorenzo

AU - Valentino, Sonia

AU - Barbati, Elisa

AU - Nebuloni, Manuela

AU - Mantovani, Alberto

AU - Garlanda, Cecilia

PY - 2013

Y1 - 2013

N2 - Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.

AB - Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.

KW - Cancer-associated inflammation

KW - Glioma

KW - Immunohistochemistry

KW - Macrophage

KW - PTX3

UR - http://www.scopus.com/inward/record.url?scp=84878658286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878658286&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2013.04.009

DO - 10.1016/j.jneuroim.2013.04.009

M3 - Article

C2 - 23664694

AN - SCOPUS:84878658286

VL - 260

SP - 99

EP - 106

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -

The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this