Abstract
Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.
Original language | English |
---|---|
Pages (from-to) | 99-106 |
Number of pages | 8 |
Journal | Journal of Neuroimmunology |
Volume | 260 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 2013 |
Keywords
- Cancer-associated inflammation
- Glioma
- Immunohistochemistry
- Macrophage
- PTX3
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology