The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas

Marco Locatelli, Stefano Ferrero, Filippo Martinelli Boneschi, Leonardo Boiocchi, Mario Zavanone, Sergio Maria Gaini, Lorenzo Bello, Sonia Valentino, Elisa Barbati, Manuela Nebuloni, Alberto Mantovani, Cecilia Garlanda

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalJournal of Neuroimmunology
Volume260
Issue number1-2
DOIs
Publication statusPublished - 2013

Keywords

  • Cancer-associated inflammation
  • Glioma
  • Immunohistochemistry
  • Macrophage
  • PTX3

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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