The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas

Marco Locatelli, Stefano Ferrero, Filippo Martinelli Boneschi, Leonardo Boiocchi, Mario Zavanone, Sergio Maria Gaini, Lorenzo Bello, Sonia Valentino, Elisa Barbati, Manuela Nebuloni, Alberto Mantovani, Cecilia Garlanda

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalJournal of Neuroimmunology
Volume260
Issue number1-2
DOIs
Publication statusPublished - 2013

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Glioma
Inflammation
Neoplasms
Logistic Models
Innate Immunity
Immunohistochemistry

Keywords

  • Cancer-associated inflammation
  • Glioma
  • Immunohistochemistry
  • Macrophage
  • PTX3

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas. / Locatelli, Marco; Ferrero, Stefano; Martinelli Boneschi, Filippo; Boiocchi, Leonardo; Zavanone, Mario; Maria Gaini, Sergio; Bello, Lorenzo; Valentino, Sonia; Barbati, Elisa; Nebuloni, Manuela; Mantovani, Alberto; Garlanda, Cecilia.

In: Journal of Neuroimmunology, Vol. 260, No. 1-2, 2013, p. 99-106.

Research output: Contribution to journalArticle

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AU - Zavanone, Mario

AU - Maria Gaini, Sergio

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