The long pentraxin PTX3 as a key component of humoral innate immunity and a candidate diagnostic for inflammatory diseases

Sébastien Jaillon, Eduardo Bonavita, Stefania Gentile, Marcello Rubino, Ilaria Laface, Cecilia Garlanda, Alberto Mantovani

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The innate immune system is composed of a cellular arm and a humoral arm. Components of the humoral arm include members of the complement cascade and soluble pattern recognition molecules (PRMs). These PRMs recognize pathogen-associated molecular patterns and are functional ancestors of antibodies, playing a role in complement activation, opsonization and agglutination. Pentraxins consist of a set of multimeric soluble proteins and represent the prototypic components of humoral innate immunity. The prototypic long pentraxin PTX3 is highly conserved in evolution and produced by somatic and innate immune cells after proinflammatory stimuli. PTX3 interacts with a set of self, nonself and modified self ligands and exerts essential roles in innate immunity, inflammation control and matrix deposition. In addition, translational studies suggest that PTX3 may be a useful biomarker of human pathologies complementary to C-reactive protein. In this study, we will review the general functions of pentraxins in innate immunity and inflammation, focusing our attention on the prototypic long pentraxin PTX3.

Original languageEnglish
Pages (from-to)165-178
Number of pages14
JournalInternational Archives of Allergy and Immunology
Volume165
Issue number3
DOIs
Publication statusPublished - Jan 21 2014

Fingerprint

Humoral Immunity
Innate Immunity
Clonal Evolution
Inflammation
Complement Activation
Agglutination
C-Reactive Protein
Immune System
Biomarkers
Pathology
Ligands
Antibodies
Proteins

Keywords

  • Clinical biomarkers
  • Inflammation
  • Innate immunity
  • Pattern recognition molecules
  • Pentraxin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Medicine(all)

Cite this

The long pentraxin PTX3 as a key component of humoral innate immunity and a candidate diagnostic for inflammatory diseases. / Jaillon, Sébastien; Bonavita, Eduardo; Gentile, Stefania; Rubino, Marcello; Laface, Ilaria; Garlanda, Cecilia; Mantovani, Alberto.

In: International Archives of Allergy and Immunology, Vol. 165, No. 3, 21.01.2014, p. 165-178.

Research output: Contribution to journalArticle

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