The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility

Barbara Bottazzi, Antonio Bastone, Andrea Doni, Cecilia Garlanda, Sonia Valentino, Livija Deban, Virginia Maina, Alessia Cotena, Federica Moalli, Luca Vago, Antonietta Salustri, Luigina Romani, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

The long pentraxin 3 (PTX3) is member of a complex superfamily of multifunctional proteins characterized by a cyclic multimeric structure. PTX3 is highly conserved in evolution and is produced by innate-immunity cells in response to proinflammatory signals and Toll-like receptor engagement. PTX3 plays complex, nonredundant functions in vivo, acting as a predecessor of antibodies, recognizing microbes, activating complement, facilitating pathogen recognition by phagocytes, and hence, playing a nonredundant role in resistance against selected pathogens. In addition, PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. Thus, the prototypic long pentraxin PTX3 is a multifunctional, soluble pattern recognition receptor acting as a nonredundant component of the humoral arm of innate immunity and involved in matrix deposition and female fertility.

Original languageEnglish
Pages (from-to)909-912
Number of pages4
JournalJournal of Leukocyte Biology
Volume79
Issue number5
DOIs
Publication statusPublished - May 2006

Keywords

  • Acute myocardial infarction
  • Acute-phase protein
  • Extracellular matrix

ASJC Scopus subject areas

  • Cell Biology

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