The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: Interplay with cellular innate immunity

Barbara Bottazzi, Cecilia Garlanda, Alessia Cotena, Federica Moalli, Sebastien Jaillon, Livija Deban, Alberto Mantovani

Research output: Contribution to journalArticle

Abstract

The innate immune system consists of a cellular arm and a humoral arm. Components of humoral immunity include diverse molecular families, which represent functional ancestors of antibodies. They play a key role as effectors and modulators of innate resistance in animals and humans, interacting with cellular innate immunity. The prototypic long pentraxin, pentraxin 3 (PTX3), represents a case in point of this interplay. Gene targeting of this evolutionarily conserved long pentraxin has unequivocally defined its role at the crossroads of innate immunity, inflammation, matrix deposition, and female fertility. Phagocytes represent a key source of this fluid-phase pattern recognition receptor, which, in turn, facilitates microbial recognition by phagocytes acting as an opsonin. Moreover, PTX3 has modulatory functions on innate immunity and inflammation. Here, we review the studies on PTX3 which emphasize the complexity and complementarity of the crosstalk between the cellular and humoral arms of innate immunity.

Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalImmunological Reviews
Volume227
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Complement
  • Inflammation
  • Innate immunity
  • Pentraxin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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