The long pentraxin PTX3 in vascular pathology

Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi, Giuseppe Peri, Andrea Doni, Yeny Martinez de la Torre, Roberto Latini

Research output: Contribution to journalArticlepeer-review

Abstract

Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. In addition, PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. Thus, the prototypic long pentraxin PTX3 is a multifunctional soluble pattern recognition receptor acting as a non-redundant component of the humoral arm of innate immunity and involved in tuning inflammation, in matrix deposition and female fertility.

Original languageEnglish
Pages (from-to)326-330
Number of pages5
JournalVascular Pharmacology
Volume45
Issue number5
DOIs
Publication statusPublished - Nov 2006

Keywords

  • Pentraxin
  • PTX3
  • Vascular pathology

ASJC Scopus subject areas

  • Pharmacology

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