The long QT syndrome: A prospective international study

A. J. Moss, P. J. Schwartz, R. S. Crampton, E. Locati, E. Carleen

Research output: Contribution to journalArticle

368 Citations (Scopus)

Abstract

During the past 4 years 196 patients with the idiopathic long QT syndrome were enrolled in a prospective international study conducted to obtain a better understanding of the clinical course of this unusual repolarization disorder. The mean patient age was 24 years, 64% were female, and 88% had family members with QT prolongation. During an average follow-up of 26 months per patient, four patients died suddenly (1.3% per year) and 27 patients had one or more syncopal episodes (8.6% per year). Multivariate analysis identified congenital deafness, history of syncope, female gender, and a documented episode of torsades de pointes or ventricular fibrillation as independent risk factors for postenrollment syncope or sudden death. Two types of treatment (left stellate ganglionectomy and β-blocker therapy) were associated with a significant reduction in the occurrence of cardiac events during follow-up.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalCirculation
Volume71
Issue number1
Publication statusPublished - 1985

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Long QT Syndrome
Prospective Studies
Syncope
Ganglionectomy
Torsades de Pointes
Deafness
Ventricular Fibrillation
Sudden Death
Multivariate Analysis
Therapeutics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Moss, A. J., Schwartz, P. J., Crampton, R. S., Locati, E., & Carleen, E. (1985). The long QT syndrome: A prospective international study. Circulation, 71(1), 17-21.

The long QT syndrome : A prospective international study. / Moss, A. J.; Schwartz, P. J.; Crampton, R. S.; Locati, E.; Carleen, E.

In: Circulation, Vol. 71, No. 1, 1985, p. 17-21.

Research output: Contribution to journalArticle

Moss, AJ, Schwartz, PJ, Crampton, RS, Locati, E & Carleen, E 1985, 'The long QT syndrome: A prospective international study', Circulation, vol. 71, no. 1, pp. 17-21.
Moss AJ, Schwartz PJ, Crampton RS, Locati E, Carleen E. The long QT syndrome: A prospective international study. Circulation. 1985;71(1):17-21.
Moss, A. J. ; Schwartz, P. J. ; Crampton, R. S. ; Locati, E. ; Carleen, E. / The long QT syndrome : A prospective international study. In: Circulation. 1985 ; Vol. 71, No. 1. pp. 17-21.
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