The long QT syndrome in pediatric age: Prognosis and risk factor

G. Fazio, S. Pipitone, L. D'Angelo, G. Di Gesaro, L. Sutera, G. Visconti, G. Evola, G. Novo, S. Novo

Research output: Contribution to journalArticlepeer-review


Aim. Long QT syndrome is a rare arrhythmic disease with a low incidence in the general population. There are no sure clinical or electrocardiografic parameters that could lead to a correct prognostic stratification in patients affected by this syndrome. The correlation between the incidence of a sudden death or dangerous ventricular arrhythmias and the duration of QTc interval is still a controversial topic. Methods. Twenty nine children affected by QT long syndrome were admitted to the Division of Pediatric Cardiology of the Casa del Sole Hospital of Palermo (Italy). Their diagnosis was made by electrocardiogram (ECG). The average age of the patients was 7.6 years. The average follow-up was 4 years and three months. A therapy whit beta-blocker was administered to all the children. During the follow-up of 4 year and three months, patients were genotyped. Twenty-three out of 29 children had at least one relative affected by the syndrome. Three of them had a familiar dead because of this syndrome and everyone had a duration of maximum QTc higher than the cut off (P=0.0002). All the people who died had not followed the therapy with beta-blocker. Patients with a maximum QTc recorded

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalMinerva Cardioangiologica
Issue number4
Publication statusPublished - Aug 2008


  • Arrhythmias, cardiac
  • Death, sudden
  • Long QT syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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