The long-term effect of AHSCT on MRI measures of MS evolution: A five-year follow-up study

L. Roccatogliata, M. A. Rocca, P. Valsasina, L. Bonzano, M. P. Sormani, R. Saccardi, G. L. Mancardi, Massimo Filippi, M. G. Marrosu, G. La Nasa, E. Cocco, V. Cherchi, A. Lugaresi, P. Di Bartolomeo, D. Farina, C. Ialori, A. Tartaro, L. Massacesi, F. Pagliai, A. BosiA. Repice, A. Konze, F. Sardanelli, E. Capello, A. Murialdo, F. Gualandi, R. C. Parodi, L. Dogliotti, A. Marmont, M. Inglese, G. Comi, A. Donelli, E. Merelli, F. Casoni, F. Cavalleri, A. Bertolotto, A. Guerrasio, M. Capobianco, S. Duca, G. Meucci, F. Papineschi, S. Mosti, A. Abruzzese

Research output: Contribution to journalArticlepeer-review

Abstract

Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decrease of the rate of brain atrophy after the second year following treatment.

Original languageEnglish
Pages (from-to)1068-1070
Number of pages3
JournalMultiple Sclerosis Journal
Volume13
Issue number8
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Atrophy
  • Autologous hematopoietic stem cell transplantation
  • Magnetic resonance imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology

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