Abstract
Little is yet known about the duration of contact sensitivity, but frequent exposure of a target to allergen seems to reduce skin reactivity. The aim of this study was to study the persistence of a specific contact sensitivity in 66 patients with alopecia areata, previously sensitized to DNCB (31 patients) and SADBE (35 patients) between 1978-1985. Patch tests were performed with 0.020 ml of different concentrations of DNCB or SADBE in acetone(0.05%, 0.10%, 0.20%, 1%). The results were read in a standardized manner. Of 66 patients, 47 (71%) had positive reactions and 19 (29%) negative. 8 of the 19 negative patients had been treated with DNCB, 11 with SADBE. Approximately 1/3 of the patients previously sensitized had lost their original sensitivity, and this did not seem to be time-dependent. This phenomenon seemed to be clinically correlated because the majority of the patients were from the 'low responders' group. We think that acquired unresponsiveness to topical antigen in man is a possible phenomenon, but that it occurs more rarely than in mice and guinea pigs.
| Original language | English |
|---|---|
| Pages (from-to) | 183-186 |
| Number of pages | 4 |
| Journal | Contact Dermatitis |
| Volume | 24 |
| Issue number | 3 |
| Publication status | Published - 1991 |
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Keywords
- alopecia areata
- contact sensitization
- DNCB
- loss with time
- man
- SADBE
ASJC Scopus subject areas
- Immunology
- Dermatology
- Toxicology
Cite this
The loss of contact sensitization in man. / Valsecchi, R.; Rossi, A.; Bigardi, A.; Pigatto, P. D.
In: Contact Dermatitis, Vol. 24, No. 3, 1991, p. 183-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The loss of contact sensitization in man
AU - Valsecchi, R.
AU - Rossi, A.
AU - Bigardi, A.
AU - Pigatto, P. D.
PY - 1991
Y1 - 1991
N2 - Little is yet known about the duration of contact sensitivity, but frequent exposure of a target to allergen seems to reduce skin reactivity. The aim of this study was to study the persistence of a specific contact sensitivity in 66 patients with alopecia areata, previously sensitized to DNCB (31 patients) and SADBE (35 patients) between 1978-1985. Patch tests were performed with 0.020 ml of different concentrations of DNCB or SADBE in acetone(0.05%, 0.10%, 0.20%, 1%). The results were read in a standardized manner. Of 66 patients, 47 (71%) had positive reactions and 19 (29%) negative. 8 of the 19 negative patients had been treated with DNCB, 11 with SADBE. Approximately 1/3 of the patients previously sensitized had lost their original sensitivity, and this did not seem to be time-dependent. This phenomenon seemed to be clinically correlated because the majority of the patients were from the 'low responders' group. We think that acquired unresponsiveness to topical antigen in man is a possible phenomenon, but that it occurs more rarely than in mice and guinea pigs.
AB - Little is yet known about the duration of contact sensitivity, but frequent exposure of a target to allergen seems to reduce skin reactivity. The aim of this study was to study the persistence of a specific contact sensitivity in 66 patients with alopecia areata, previously sensitized to DNCB (31 patients) and SADBE (35 patients) between 1978-1985. Patch tests were performed with 0.020 ml of different concentrations of DNCB or SADBE in acetone(0.05%, 0.10%, 0.20%, 1%). The results were read in a standardized manner. Of 66 patients, 47 (71%) had positive reactions and 19 (29%) negative. 8 of the 19 negative patients had been treated with DNCB, 11 with SADBE. Approximately 1/3 of the patients previously sensitized had lost their original sensitivity, and this did not seem to be time-dependent. This phenomenon seemed to be clinically correlated because the majority of the patients were from the 'low responders' group. We think that acquired unresponsiveness to topical antigen in man is a possible phenomenon, but that it occurs more rarely than in mice and guinea pigs.
KW - alopecia areata
KW - contact sensitization
KW - DNCB
KW - loss with time
KW - man
KW - SADBE
UR - http://www.scopus.com/inward/record.url?scp=0025906011&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025906011&partnerID=8YFLogxK
M3 - Article
VL - 24
SP - 183
EP - 186
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 3
ER -