The loss of macular ganglion cells begins from the early stages of disease and correlates with brain atrophy in multiple sclerosis patients

Anna M. Pietroboni, Laura Dell’Arti, Michela Caprioli, Marta Scarioni, Tiziana Carandini, Andrea Arighi, Laura Ghezzi, Giorgio G. Fumagalli, Milena A. De Riz, Paola Basilico, Annalisa Colombi, Eleonora Benatti, Fabio Triulzi, Elio Scarpini, Francesco Viola, Daniela Galimberti

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: The importance of neurodegeneration in multiple sclerosis (MS) is increasingly well recognized. Objectives: To evaluate retinal pathology using optical coherence tomography (OCT) and to investigate possible associations between retinal layers’ thickness and specific patterns of gray matter volume in patients with a new diagnosis of MS. Methods: A total of 31 patients underwent OCT scans and brain magnetic resonance imaging. In total, 30 controls underwent the same OCT procedure. The association between focal cortical volume and OCT measurements was investigated with voxel-based morphometry (VBM). Results: Compared to controls, patients’ macular retinal nerve fiber layer (mRNFL), macular ganglion cell layer (mGCL), macular inner plexiform layer (mIPL), and macular ganglion cell-inner plexiform layer (mGCIPL) thickness were significantly reduced (p = 0.0009, p = 0.0003, p = 0.0049, and p = 0.0007, respectively). Peripapillary RNFL (pRNFL) and temporal sector pRNFL (T-pRNFL) did not show any significant changes, although there was a trend toward T-pRNFL thinning (p = 0.0254). VBM analysis showed that mGCIPL and pRNFL were significantly correlated with the volume reduction of occipital-parietal cortex (p < 0.005). Conclusion: mRNFL, mGCL, and mIPL are significantly reduced in MS patients without concomitant pRNFL thinning. These retinal changes show a significant association with cortical regions that are known to be important for visuospatial performance.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalMultiple Sclerosis Journal
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

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Optical Coherence Tomography
Ganglia
Multiple Sclerosis
Atrophy
Brain
Nerve Fibers
Occipital Lobe
Parietal Lobe
Magnetic Resonance Imaging
Pathology

Keywords

  • atrophy
  • axonal loss
  • functional MRI
  • MRI
  • Multiple sclerosis
  • outcome measurement

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

The loss of macular ganglion cells begins from the early stages of disease and correlates with brain atrophy in multiple sclerosis patients. / Pietroboni, Anna M.; Dell’Arti, Laura; Caprioli, Michela; Scarioni, Marta; Carandini, Tiziana; Arighi, Andrea; Ghezzi, Laura; Fumagalli, Giorgio G.; De Riz, Milena A.; Basilico, Paola; Colombi, Annalisa; Benatti, Eleonora; Triulzi, Fabio; Scarpini, Elio; Viola, Francesco; Galimberti, Daniela.

In: Multiple Sclerosis Journal, Vol. 25, No. 1, 01.01.2019, p. 31-38.

Research output: Contribution to journalArticle

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abstract = "Background: The importance of neurodegeneration in multiple sclerosis (MS) is increasingly well recognized. Objectives: To evaluate retinal pathology using optical coherence tomography (OCT) and to investigate possible associations between retinal layers’ thickness and specific patterns of gray matter volume in patients with a new diagnosis of MS. Methods: A total of 31 patients underwent OCT scans and brain magnetic resonance imaging. In total, 30 controls underwent the same OCT procedure. The association between focal cortical volume and OCT measurements was investigated with voxel-based morphometry (VBM). Results: Compared to controls, patients’ macular retinal nerve fiber layer (mRNFL), macular ganglion cell layer (mGCL), macular inner plexiform layer (mIPL), and macular ganglion cell-inner plexiform layer (mGCIPL) thickness were significantly reduced (p = 0.0009, p = 0.0003, p = 0.0049, and p = 0.0007, respectively). Peripapillary RNFL (pRNFL) and temporal sector pRNFL (T-pRNFL) did not show any significant changes, although there was a trend toward T-pRNFL thinning (p = 0.0254). VBM analysis showed that mGCIPL and pRNFL were significantly correlated with the volume reduction of occipital-parietal cortex (p < 0.005). Conclusion: mRNFL, mGCL, and mIPL are significantly reduced in MS patients without concomitant pRNFL thinning. These retinal changes show a significant association with cortical regions that are known to be important for visuospatial performance.",
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AU - Pietroboni, Anna M.

AU - Dell’Arti, Laura

AU - Caprioli, Michela

AU - Scarioni, Marta

AU - Carandini, Tiziana

AU - Arighi, Andrea

AU - Ghezzi, Laura

AU - Fumagalli, Giorgio G.

AU - De Riz, Milena A.

AU - Basilico, Paola

AU - Colombi, Annalisa

AU - Benatti, Eleonora

AU - Triulzi, Fabio

AU - Scarpini, Elio

AU - Viola, Francesco

AU - Galimberti, Daniela

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