Abstract
Background: The importance of neurodegeneration in multiple sclerosis (MS) is increasingly well recognized. Objectives: To evaluate retinal pathology using optical coherence tomography (OCT) and to investigate possible associations between retinal layers’ thickness and specific patterns of gray matter volume in patients with a new diagnosis of MS. Methods: A total of 31 patients underwent OCT scans and brain magnetic resonance imaging. In total, 30 controls underwent the same OCT procedure. The association between focal cortical volume and OCT measurements was investigated with voxel-based morphometry (VBM). Results: Compared to controls, patients’ macular retinal nerve fiber layer (mRNFL), macular ganglion cell layer (mGCL), macular inner plexiform layer (mIPL), and macular ganglion cell-inner plexiform layer (mGCIPL) thickness were significantly reduced (p = 0.0009, p = 0.0003, p = 0.0049, and p = 0.0007, respectively). Peripapillary RNFL (pRNFL) and temporal sector pRNFL (T-pRNFL) did not show any significant changes, although there was a trend toward T-pRNFL thinning (p = 0.0254). VBM analysis showed that mGCIPL and pRNFL were significantly correlated with the volume reduction of occipital-parietal cortex (p < 0.005). Conclusion: mRNFL, mGCL, and mIPL are significantly reduced in MS patients without concomitant pRNFL thinning. These retinal changes show a significant association with cortical regions that are known to be important for visuospatial performance.
| Original language | English |
|---|---|
| Pages (from-to) | 31-38 |
| Number of pages | 8 |
| Journal | Multiple Sclerosis Journal |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- atrophy
- axonal loss
- functional MRI
- MRI
- Multiple sclerosis
- outcome measurement
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
The loss of macular ganglion cells begins from the early stages of disease and correlates with brain atrophy in multiple sclerosis patients. / Pietroboni, Anna M.; Dell’Arti, Laura; Caprioli, Michela; Scarioni, Marta; Carandini, Tiziana; Arighi, Andrea; Ghezzi, Laura; Fumagalli, Giorgio G.; De Riz, Milena A.; Basilico, Paola; Colombi, Annalisa; Benatti, Eleonora; Triulzi, Fabio; Scarpini, Elio; Viola, Francesco; Galimberti, Daniela.
In: Multiple Sclerosis Journal, Vol. 25, No. 1, 01.01.2019, p. 31-38.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The loss of macular ganglion cells begins from the early stages of disease and correlates with brain atrophy in multiple sclerosis patients
AU - Pietroboni, Anna M.
AU - Dell’Arti, Laura
AU - Caprioli, Michela
AU - Scarioni, Marta
AU - Carandini, Tiziana
AU - Arighi, Andrea
AU - Ghezzi, Laura
AU - Fumagalli, Giorgio G.
AU - De Riz, Milena A.
AU - Basilico, Paola
AU - Colombi, Annalisa
AU - Benatti, Eleonora
AU - Triulzi, Fabio
AU - Scarpini, Elio
AU - Viola, Francesco
AU - Galimberti, Daniela
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: The importance of neurodegeneration in multiple sclerosis (MS) is increasingly well recognized. Objectives: To evaluate retinal pathology using optical coherence tomography (OCT) and to investigate possible associations between retinal layers’ thickness and specific patterns of gray matter volume in patients with a new diagnosis of MS. Methods: A total of 31 patients underwent OCT scans and brain magnetic resonance imaging. In total, 30 controls underwent the same OCT procedure. The association between focal cortical volume and OCT measurements was investigated with voxel-based morphometry (VBM). Results: Compared to controls, patients’ macular retinal nerve fiber layer (mRNFL), macular ganglion cell layer (mGCL), macular inner plexiform layer (mIPL), and macular ganglion cell-inner plexiform layer (mGCIPL) thickness were significantly reduced (p = 0.0009, p = 0.0003, p = 0.0049, and p = 0.0007, respectively). Peripapillary RNFL (pRNFL) and temporal sector pRNFL (T-pRNFL) did not show any significant changes, although there was a trend toward T-pRNFL thinning (p = 0.0254). VBM analysis showed that mGCIPL and pRNFL were significantly correlated with the volume reduction of occipital-parietal cortex (p < 0.005). Conclusion: mRNFL, mGCL, and mIPL are significantly reduced in MS patients without concomitant pRNFL thinning. These retinal changes show a significant association with cortical regions that are known to be important for visuospatial performance.
AB - Background: The importance of neurodegeneration in multiple sclerosis (MS) is increasingly well recognized. Objectives: To evaluate retinal pathology using optical coherence tomography (OCT) and to investigate possible associations between retinal layers’ thickness and specific patterns of gray matter volume in patients with a new diagnosis of MS. Methods: A total of 31 patients underwent OCT scans and brain magnetic resonance imaging. In total, 30 controls underwent the same OCT procedure. The association between focal cortical volume and OCT measurements was investigated with voxel-based morphometry (VBM). Results: Compared to controls, patients’ macular retinal nerve fiber layer (mRNFL), macular ganglion cell layer (mGCL), macular inner plexiform layer (mIPL), and macular ganglion cell-inner plexiform layer (mGCIPL) thickness were significantly reduced (p = 0.0009, p = 0.0003, p = 0.0049, and p = 0.0007, respectively). Peripapillary RNFL (pRNFL) and temporal sector pRNFL (T-pRNFL) did not show any significant changes, although there was a trend toward T-pRNFL thinning (p = 0.0254). VBM analysis showed that mGCIPL and pRNFL were significantly correlated with the volume reduction of occipital-parietal cortex (p < 0.005). Conclusion: mRNFL, mGCL, and mIPL are significantly reduced in MS patients without concomitant pRNFL thinning. These retinal changes show a significant association with cortical regions that are known to be important for visuospatial performance.
KW - atrophy
KW - axonal loss
KW - functional MRI
KW - MRI
KW - Multiple sclerosis
KW - outcome measurement
UR - http://www.scopus.com/inward/record.url?scp=85037741841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85037741841&partnerID=8YFLogxK
U2 - 10.1177/1352458517740214
DO - 10.1177/1352458517740214
M3 - Article
AN - SCOPUS:85037741841
VL - 25
SP - 31
EP - 38
JO - Multiple Sclerosis
JF - Multiple Sclerosis
SN - 1352-4585
IS - 1
ER -