TY - JOUR
T1 - The low risk of hepatitis C virus transmission among sexual partners of hepatitis C-infected hemophilic males
T2 - An international, multicenter study
AU - Brettler, D. B.
AU - Mannucci, P. M.
AU - Gringeri, A.
AU - Rasko, J. E.
AU - Forsberg, A. D.
AU - Rumi, M. G.
AU - Garsia, R. J.
AU - Rickard, K. A.
AU - Colombo, M.
PY - 1992/7/15
Y1 - 1992/7/15
N2 - To study the transmission rate of hepatitis C virus (HCV) in the female sexual partners of antibody-positive hemophilic males, 106 partners from three hemophilia centers located in Europe, America, and Australia were tested for HCV seropositivity using a first-generation enzyme-linked immunosorbent assay (ELISA-1) and, subsequently, a second-generation ELISA (ELISA-2) and a supplemental recombinant immunoblot assay. Additionally, the cohort was tested for the presence of antibody to the human immunodeficiency virus type-1 and hepatitis B virus markers. No female partner was HCV antibody-positive using the ELISA-1 test, whereas five were seropositive by the ELISA-2 test. Three of these five female partners were seropositive on the supplemental test the remaining two having indeterminate results, for an overall prevalence of 2.7%. Thus, even with the use of sensitive testing, the prevalence of HCV infection remains low in this cohort, showing that the efficiency of heterosexual transmission of HCV is poor.
AB - To study the transmission rate of hepatitis C virus (HCV) in the female sexual partners of antibody-positive hemophilic males, 106 partners from three hemophilia centers located in Europe, America, and Australia were tested for HCV seropositivity using a first-generation enzyme-linked immunosorbent assay (ELISA-1) and, subsequently, a second-generation ELISA (ELISA-2) and a supplemental recombinant immunoblot assay. Additionally, the cohort was tested for the presence of antibody to the human immunodeficiency virus type-1 and hepatitis B virus markers. No female partner was HCV antibody-positive using the ELISA-1 test, whereas five were seropositive by the ELISA-2 test. Three of these five female partners were seropositive on the supplemental test the remaining two having indeterminate results, for an overall prevalence of 2.7%. Thus, even with the use of sensitive testing, the prevalence of HCV infection remains low in this cohort, showing that the efficiency of heterosexual transmission of HCV is poor.
UR - http://www.scopus.com/inward/record.url?scp=0026696752&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026696752&partnerID=8YFLogxK
M3 - Article
C2 - 1627805
AN - SCOPUS:0026696752
VL - 80
SP - 540
EP - 543
JO - Blood
JF - Blood
SN - 0006-4971
IS - 2
ER -