The lullaby of the sun: the role of vitamin D in sleep disturbance

Giovanna Muscogiuri, Luigi Barrea, Marianna Scannapieco, Carolina Di Somma, Massimo Scacchi, Gianluca Aimaretti, Silvia Savastano, Annamaria Colao, Paolo Marzullo

Research output: Contribution to journalReview articlepeer-review


Vitamin D is a pro-hormone belonging to the category of the fat-soluble group of vitamins; it is obtained more from solar exposure and in smaller quantities through feeding. Although vitamin D has traditionally been shown to be involved in calcium homeostasis and bone health, recent studies have found a positive association between vitamin D and sleep. In particular, clinical studies in humans indicate that low levels of vitamin D are correlated with poor quality and short sleep duration. The mechanism by which this association is explained is still unclear. However, vitamin D receptors have been found in the brain regions involved in sleep regulation, and vitamin D appears to be involved in regulating the sleep-wake cycle. The current review summarizes the available evidence regarding the association between vitamin D and sleep, focusing on both clinical and preclinical studies.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalSleep Medicine
Publication statusPublished - Feb 2019


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