The m-chlorophenylpiperazine test in cluster headache: A study on central serotoninergic activity

M. Leone, A. Attanasio, D. Croci, G. Libro, L. Grazzi, D. D'Amico, A. Nespolo, G. Bussone

Research output: Contribution to journalArticlepeer-review

Abstract

The central serotoninergic agonist m-chlorophenylpiperazine (m-CPP) stimulates several 5HT receptor subtypes. It induces the release of both cortisol and prolactin (PRL). In this study we investigated central serotoninergic responsiveness in cluster headache by monitoring cortisol and PRL responses to m-CPP administration. Twenty-three patients with episodic cluster headache and 17 sex-matched and age-matched healthy subjects were studied. The cluster headache patients were tested during a cluster period, and none were receiving prophylaxis. A single oral dose of m-CPP, 0.5 mg/kg, was given at time 0. Blood samples were drawn at -30, 0, 30, 60, 90, 120, 150 and 180 min. PRL and cortisol levels were assayed in the samples. PRL and cortisol delta maxima (delta maximum = maximum response-baseline level at time 0/baseline level at time 0) were evaluated in each patient and mean values compared. Serum levels of m-CPP were detected by HPLC and correlated to hormonal responses. Reduced cortisol (p

Original languageEnglish
Pages (from-to)666-672
Number of pages7
JournalCephalalgia
Volume17
Issue number6
DOIs
Publication statusPublished - 1997

Keywords

  • Cluster headache
  • Cortisol and PRL
  • Hypothalamus
  • m- chlorophenylpiperazine
  • Pathogenesis
  • Serotonin

ASJC Scopus subject areas

  • Clinical Neurology

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