Cerebral serotoninergic system play a key role in pain modulation and cerebrovascular responses and it has been proposed to be involved in the pathogenesis of migraine and duster headache (CH). m-Chlorophenylpiperazine (m-CPP), a cerebral serotoninergic agonist, induces the release of both cortisol and PRL and we employed it to investigate central serotoninergic system in migraine and CH. Low back pain patients and healthy subjects were the control groups. Forty-five patients with episodic CH headache were studied: 23 were in cluster period and 12 in remission; 11 were migraine without aura sufferers, 6 had low back pain and 17 were healthy subjects. A single oral dose of m-CPP, 0.5 mg/Kg, was given. PRL and cortisol delta maxima (delta maximum = maximum response - baseline level at time O/ baseline level at time 0) were evaluated in each patient and mean values compared. Reduced cortisol (P=0.04) and increased PRL (P=0.03) delta maxima were observed in cluster period CH patients and reduced cortisol (P=0.04) and PRL (P=0.01) delta maxima were observed in CH patients during remission compared to controls. This study suggest impaired central serotoninergic function in cluster headache.
|Number of pages||1|
|Journal||Italian Journal of Neurological Sciences|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology