The M2 haplotype in the ANXA5 gene is an independent risk factor for idiopathic small-for-gestational age newborns

G. Tiscia, D. Colaizzo, G. Favuzzi, P. Vergura, P. Martinelli, M. Margaglione, E. Grandone

Research output: Contribution to journalArticle

Abstract

Hereditary thrombophilias can impair vascular placental functions and predispose to the birth of small-for-gestational age (SGA) babies. The placental anticoagulant protein annexin A5 (ANXA5) may contribute to this process. A functional haplotype (M2) within the ANXA5 gene is associated with fetal loss and venous thrombosis. This study investigated the prevalence of the M2 haplotype in a group of women with idiopathic SGA newborn babies. Seventy-eight women with at least one previous unexplained SGA birth and 195 controls all from Southern Italy were investigated. Hereditary thrombophilia was found in 13 (16.5%) cases and 21 (11%) controls (P

Original languageEnglish
Article numbergas023
Pages (from-to)510-513
Number of pages4
JournalMolecular Human Reproduction
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 2012

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Keywords

  • Polymorphism
  • Pregnancy

ASJC Scopus subject areas

  • Molecular Biology
  • Embryology
  • Cell Biology
  • Genetics
  • Developmental Biology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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