The macrophage as the social interconnection within the immune system

Luigi Varesio, Santo Landolfo, Mirella Giovarelli, Guido Forni

Research output: Contribution to journalArticlepeer-review


Mammalian macrophages are presented as the social interconnection between the different mechanisms of the immune system, since they appear in a variety of roles-as effectors, helpers, and suppressors-in nearly all immune reactions. Their phylogenetic antiquity and their special task of picking up antigen signals and representing them on their cell membrane have made them the pivot for immune system evolution.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalDevelopmental and Comparative Immunology
Issue numberC
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Developmental Biology
  • Immunology


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