Macrophages are specialized but versatile cells that participate in a range of physiological and immune related processes. The macrophage repertoire of coding and regulatory RNA provides tools to understand cell identity, cell function, role in disease, and ultimately define cell specific therapeutic targets. Modern tools make it possible to quantify and compare global RNA levels. With this vast information a neologism of the decade, the suffix ome has been combined with transcript to form transcriptome, a new word to define the totality of transcripts that characterize a cell. In this chapter we discuss the macrophage transcriptome and how its definition is contributing to a deeper understanding of this cell identity and function.
|Title of host publication||Macrophages: Biology and Role in the Pathology of Diseases|
|Publisher||Springer New York|
|Number of pages||27|
|ISBN (Print)||9781493913114, 1493913107, 9781493913107|
|Publication status||Published - May 1 2014|
ASJC Scopus subject areas
- Immunology and Microbiology(all)