The macrophage transcriptome

Ronny Milde, Matthieu Pesant, Massimo Locati, Fernando O. Martinez Estrada

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Macrophages are specialized but versatile cells that participate in a range of physiological and immune related processes. The macrophage repertoire of coding and regulatory RNA provides tools to understand cell identity, cell function, role in disease, and ultimately define cell specific therapeutic targets. Modern tools make it possible to quantify and compare global RNA levels. With this vast information a neologism of the decade, the suffix ome has been combined with transcript to form transcriptome, a new word to define the totality of transcripts that characterize a cell. In this chapter we discuss the macrophage transcriptome and how its definition is contributing to a deeper understanding of this cell identity and function.

Original languageEnglish
Title of host publicationMacrophages: Biology and Role in the Pathology of Diseases
PublisherSpringer New York
Pages559-585
Number of pages27
ISBN (Print)9781493913114, 1493913107, 9781493913107
DOIs
Publication statusPublished - May 1 2014

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ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Milde, R., Pesant, M., Locati, M., & Martinez Estrada, F. O. (2014). The macrophage transcriptome. In Macrophages: Biology and Role in the Pathology of Diseases (pp. 559-585). Springer New York. https://doi.org/10.1007/978-1-4939-1311-4_28