The main determinants of diabetes mellitus vascular complications: Endothelial dysfunction and platelet hyperaggregation

Albino Carrizzo, Carmine Izzo, Marco Oliveti, Antonia Alfano, Nicola Virtuoso, Mario Capunzo, Paola Di Pietro, Mariaconsiglia Calabrese, Eros De Simone, Sebastiano Sciarretta, Giacomo Frati, Serena Migliarino, Antonio Damato, Mariateresa Ambrosio, Francesco De Caro, Carmine Vecchione

Research output: Contribution to journalReview articlepeer-review

Abstract

Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6–8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.

Original languageEnglish
Article number2968
JournalInternational Journal of Molecular Sciences
Volume19
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

Keywords

  • Diabetes
  • Endothelial dysfunction
  • Molecular mechanisms
  • Platelets activation

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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