The main determinants of diabetes mellitus vascular complications: Endothelial dysfunction and platelet hyperaggregation

Albino Carrizzo; Carmine Izzo; Marco Oliveti; Antonia Alfano; Nicola Virtuoso; Mario Capunzo; Paola Di Pietro; Mariaconsiglia Calabrese; Eros De Simone; Sebastiano Sciarretta; Giacomo Frati; Serena Migliarino; Antonio Damato; Mariateresa Ambrosio; Francesco De Caro; Carmine Vecchione

doi:10.3390/ijms19102968

The main determinants of diabetes mellitus vascular complications: Endothelial dysfunction and platelet hyperaggregation

Albino Carrizzo, Carmine Izzo, Marco Oliveti, Antonia Alfano, Nicola Virtuoso, Mario Capunzo, Paola Di Pietro, Mariaconsiglia Calabrese, Eros De Simone, Sebastiano Sciarretta, Giacomo Frati, Serena Migliarino, Antonio Damato, Mariateresa Ambrosio, Francesco De Caro, Carmine Vecchione

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Research output: Contribution to journal › Review article › peer-review

Abstract

Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6–8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.

Original language	English
Article number	2968
Journal	International Journal of Molecular Sciences
Volume	19
Issue number	10
DOIs	https://doi.org/10.3390/ijms19102968
Publication status	Published - Oct 1 2018

Keywords

Diabetes
Endothelial dysfunction
Molecular mechanisms
Platelets activation

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms19102968

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Carrizzo, A., Izzo, C., Oliveti, M., Alfano, A., Virtuoso, N., Capunzo, M., Di Pietro, P., Calabrese, M., De Simone, E., Sciarretta, S., Frati, G., Migliarino, S., Damato, A., Ambrosio, M., De Caro, F., & Vecchione, C. (2018). The main determinants of diabetes mellitus vascular complications: Endothelial dysfunction and platelet hyperaggregation. International Journal of Molecular Sciences, 19(10), [2968]. https://doi.org/10.3390/ijms19102968

Carrizzo, A, Izzo, C, Oliveti, M, Alfano, A, Virtuoso, N, Capunzo, M, Di Pietro, P, Calabrese, M, De Simone, E, Sciarretta, S , Frati, G, Migliarino, S, Damato, A, Ambrosio, M, De Caro, F & Vecchione, C 2018, 'The main determinants of diabetes mellitus vascular complications: Endothelial dysfunction and platelet hyperaggregation', International Journal of Molecular Sciences, vol. 19, no. 10, 2968. https://doi.org/10.3390/ijms19102968

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abstract = "Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6–8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.",

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AU - Capunzo, Mario

AU - Di Pietro, Paola

AU - Calabrese, Mariaconsiglia

AU - De Simone, Eros

AU - Sciarretta, Sebastiano

AU - Frati, Giacomo

AU - Migliarino, Serena

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AU - Ambrosio, Mariateresa

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AB - Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6–8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.

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The main determinants of diabetes mellitus vascular complications: Endothelial dysfunction and platelet hyperaggregation

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Keywords

ASJC Scopus subject areas

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