Abstract
Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6–8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.
| Original language | English |
|---|---|
| Article number | 2968 |
| Journal | International Journal of Molecular Sciences |
| Volume | 19 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 1 2018 |
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Keywords
- Diabetes
- Endothelial dysfunction
- Molecular mechanisms
- Platelets activation
ASJC Scopus subject areas
- Catalysis
- Molecular Biology
- Spectroscopy
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
Cite this
The main determinants of diabetes mellitus vascular complications : Endothelial dysfunction and platelet hyperaggregation. / Carrizzo, Albino; Izzo, Carmine; Oliveti, Marco; Alfano, Antonia; Virtuoso, Nicola; Capunzo, Mario; Di Pietro, Paola; Calabrese, Mariaconsiglia; De Simone, Eros; Sciarretta, Sebastiano; Frati, Giacomo; Migliarino, Serena; Damato, Antonio; Ambrosio, Mariateresa; De Caro, Francesco; Vecchione, Carmine.
In: International Journal of Molecular Sciences, Vol. 19, No. 10, 2968, 01.10.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The main determinants of diabetes mellitus vascular complications
T2 - Endothelial dysfunction and platelet hyperaggregation
AU - Carrizzo, Albino
AU - Izzo, Carmine
AU - Oliveti, Marco
AU - Alfano, Antonia
AU - Virtuoso, Nicola
AU - Capunzo, Mario
AU - Di Pietro, Paola
AU - Calabrese, Mariaconsiglia
AU - De Simone, Eros
AU - Sciarretta, Sebastiano
AU - Frati, Giacomo
AU - Migliarino, Serena
AU - Damato, Antonio
AU - Ambrosio, Mariateresa
AU - De Caro, Francesco
AU - Vecchione, Carmine
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6–8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.
AB - Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6–8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.
KW - Diabetes
KW - Endothelial dysfunction
KW - Molecular mechanisms
KW - Platelets activation
UR - http://www.scopus.com/inward/record.url?scp=85054065762&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054065762&partnerID=8YFLogxK
U2 - 10.3390/ijms19102968
DO - 10.3390/ijms19102968
M3 - Review article
C2 - 30274207
AN - SCOPUS:85054065762
VL - 19
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 10
M1 - 2968
ER -