PPP was a randomized, open study, conducted in the setting of Italian general practice to evaluate the efficacy of aspirin and vitamin E as primary prevention of cardiovascular events in a general population of subjects with one or more risk factors. 330 general practitioners enrolled 4495 patients and followed them up for an average of 3.6±1 years. 4150 patients (92,3%) where followed to the end of the study; of the 345 lost to follow up, (7%) life or death certificates were collected in 308 cases. The study was terminated early for ethical reasons, since at intermediate evaluation aspirin was shown clearly effective in reducing significantly the incidence of major (death, MI, stroke) and minor (angina, TIA, peripheral arteriopathy, revascularization) events. Conversely vitamin E was possibly shown effective only on the prevention of peripheral arteriopathy. Finally, the feasibility of such a study, which is the first of this dimension to be carried through with italian general practitioners, is to be considered an important result in itself.
|Translated title of the contribution||The main results of PPP|
|Number of pages||15|
|Journal||Ricerca e Pratica|
|Publication status||Published - 2001|
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