The making of a professional secretory cell: Architectural and functional changes in the ER during B lymphocyte plasma cell differentiation

Luigina Tagliavacca, Tiziana Anelli, Claudio Fagioli, Alexandre Mezghrani, Elena Ruffato, Roberto Sitia

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

B lymphocytes are small cells that express antigen receptors and secrete little if any IgM. Upon encounter with antigen, they differentiate into short-lived plasma cells, which secrete large amounts of polymeric IgM. Plasma cell differentiation entails a massive development of the endoplasmic reticulum to sustain high levels of Ig production. Recent findings suggest a role for the unfolded protein response in orchestrating the architectural and functional changes during terminal plasma cell differentiation.

Original languageEnglish
Pages (from-to)1273-1277
Number of pages5
JournalBiological Chemistry
Volume384
Issue number9
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

Lymphocytes
Plasma Cells
Cell Differentiation
B-Lymphocytes
Plasmas
Unfolded Protein Response
Antigen Receptors
Endoplasmic Reticulum
Immunoglobulin M
Antigens
Proteins

Keywords

  • B lymphocyte differentiation
  • Endoplasmic reticulum
  • ER-associated degradation
  • IgM secretion
  • Plasma cells
  • Unfolded protein response

ASJC Scopus subject areas

  • Biochemistry

Cite this

The making of a professional secretory cell : Architectural and functional changes in the ER during B lymphocyte plasma cell differentiation. / Tagliavacca, Luigina; Anelli, Tiziana; Fagioli, Claudio; Mezghrani, Alexandre; Ruffato, Elena; Sitia, Roberto.

In: Biological Chemistry, Vol. 384, No. 9, 01.09.2003, p. 1273-1277.

Research output: Contribution to journalArticle

Tagliavacca, Luigina ; Anelli, Tiziana ; Fagioli, Claudio ; Mezghrani, Alexandre ; Ruffato, Elena ; Sitia, Roberto. / The making of a professional secretory cell : Architectural and functional changes in the ER during B lymphocyte plasma cell differentiation. In: Biological Chemistry. 2003 ; Vol. 384, No. 9. pp. 1273-1277.
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