The management of acute venous thromboembolism in clinical practice - study rationale and protocol of the European PREFER in VTE Registry

Giancarlo Agnelli, Anselm K. Gitt, Rupert Bauersachs, Eva Maria Fronk, Petra Laeis, Patrick Mismetti, Manuel Monreal, Stefan N. Willich, Wolf Peter Wolf, Alexander T. Cohen, Marianne Brodmann, Peter Rief, Lisbeth Eischer, Slagjana Stoshikj, Michael Hirschl, Serge Weinmann, Peter Marschang, Fabrice Abbadie, Antoine Achkar, Azeddine AddalaFrédéric Adnet, Jean François Alexandra, Sandro Aquilanti, Abdelkader Belhassane, Anne Benaroya, Toufek Berremili, Marie Chevallier Grenot, Virginie Birr, Daniela Holtea, Christophe Bonnin, Frederic Bosler, Marie Gabrielle Bresin Durand, Dominique Brisot, Christophe Brousse, Tarodo De La Fuente, Richard Cayman, Michèle Cazaubon, Olivier Champion, Myriam Chanut, Pascal Chevalet, Jerome Connault, Cecile Durant, Joel Constans, Mihaela Cordeanu, Francis Couturaud, Karine Lacut, Laure De Dedker, Eric Decoulx, Benoit Derrien, Jean Marc Diamand, Antoine Diard, Youssef Douadi, Stephane Dupas, Santhi Samy Modeliar Remond, Marie Antoinette Sevestre, Stéphane Edhery, Nicolas Falvo, Claudia Farcas Taralunga, Emile Ferrari, Catherine Gaillard, Damien Garrigues, Jean Luc Gillet, Pascal Giordana, Claire Grange, Denis Vital-Durand, Frédérick Grare, Amine Hadj Henni, Simone Heuser, Jeannot Schmidt, Valérie Hidden-Henic, Delphine Hottin, Bernard Imbert, Gilles Pernod, Daniel Jakob, Vincent Jacquinandi, Christine Jurus, Amelie Lacoste, Jean Pierre Laroche, Myriam Martin, Cyrille Mazollier, Tahar Mersel, Gilles Miserey, Charles Nedey, Monica Nou, Isabelle Quere, Pierre Ouvry, Bernadette Peuch, Olivier Pichot, Veyre Poulain, Patrick Ray, Abed Rifai, Pierre Marie Roy, Jean Claude Saby, Frédéric Simon, Eliane Simonot-Lalandec, Dominique Stephan, Anne Tissot, Hubert Vodoungnon, Annette Adamczyk, Saskia Schnabl, Wail Al Ahmad, Heinz Weber, Christoph Axthelm, Klaus Bergmann, Ulrich Beschorner, Matthias Knittel, Karl Heinz Binias, Martin Pasligh, Mehmet Boral, Girke Friederike, Hermann Bratsch, Gunter Brauer, Sebastian Burghard, Christiane Demann, Carsten Rennebaum, Anita Demmig, Ulrich Eberlein, Frank Enger, Jens Eschenburg, Lutz Forkmann, Jürgen Frank, Holger Freischmidt, Martin Gassauer, Ilona Fritsche, Cornelia Kubicek-Hofmann, Mark Claudius Goebels, Stephan Guggenbichler, Dirk Härtel, Karsten Hartmann, Peter Heilberger, Andreas Heinsius, Michael Held, Steffen Schnupp, Georg Herman, Jörg Herold, Frank Hertrich, Henrike Hommel, Guntram Hütte, Christoph Kalka, Katja Jungandreas, Mathias Ramthor, Jan Karcher, Nicolas Werner, Susanne Karl-Wollweber, Dag Alexander Keilhau, Kerstin Kittel, Tanja Knolinski, Christina Köhler, Sebastian Werth, Ute Kopplin, Ines Körner, Kathrin Wittig, Knut Kröger, Theodoros Moysidis, Ulf Kroschel, Matthias Leschke, Tim zur Nieden, Gerhard Lübbert, Arno Lutz, Petra Wucherpfennig, Geert H. Marencke, Kai Mortensen, Michael Reppel, Heike Nelles, Kay Nestler, Axel Neumeister, Alexander Schlosser, Wolfram Oettler, Ilka Ott, Annegret Otto, Astrid Pertermann, Rahel Pfister, Lukas Pindur, Siamak Pourhassan, Diethard Predel, Thomas Pudollek, Dietrich Reimer, Cornelia Richter, Eberhad Rieker, Gabriele Rothenbücher, Brigitte Rothhagen, Simone Rudolff, Markus Stücker, Andreas Schäfer, Kristina Sonnenschein, Wolfgang Schafnitzl, Sebastian Schellong, Birgit Voigts, Martin Schiller, Thomas Schmeink, Henrik Schneider, Norbert Schön, Matthias Schulze, Udo Sechtem, Sabine Sedl, Harriet Simone Werno, Jörg Stachowitz, Marcus Thieme, Christiane Tiefenbacher, Dimitrios Tsantilas, Petra Vieth, Jürgen vom Dahl, Katharina Grün-Himmelmann, Peter von Bilderling, Thordis von Maltik, Katrin Weinrich, Marc Weyer, Eduardus Krankenhaus Köln, Peter Wirtz, Ina Wittig, Petra Zierock, Walter Ageno, Monica Caprioli, Elena Rancan, Francesco Guercini, Valeria Mommi, Maria Amitrano, Francesca Cannavacciuolo, Maurizio Amore, Sebastiano D'Antoni, Ermanno Angelini, Saverio La Forgia, Pier Luigi Antignani, Giuseppe Calandra, Andrea Arone, Francesco Perticone, Angela Sciacqua, Giovanni Asaro, Mario Bellisi, Maria Teresa Attanzio, Antonio Pinto, Valerio Attinasi, Enrico Cillari, Sabrina Sorvillo, Alberto Balbarini, Claudia Santini, Caterina Violo, Elena Banfi, Corrado Lodigiani, Doris Barcellona, Stefano Delpin, Silvia Marongiu, Giovanni Barillari, Samantha Pasca, Claudia Bartolini, Paolo Verdecchia, Mosè Bartone, Gerardo Mancuso, Ignazio Bellanuova, Salvatore Felis, Annamaria Bellizzi, Luca Masotti, Marina Bianchi, Anna Carugati, Giuseppe Bianchini, Giorgio Guarnera, Benedetta Boari, Massimo Gallerani, Mauro Pasin, Cristiano Bortoluzzi, Roberto Parisi, Caterina Brucoli, Giuseppe Palasciano, Giuseppe Camporese, Chiara Tonello, Lucia Canafoglia, Serena Rupoli, Emilia Cancellieri, Oriana Paoletti, Sophie Testa, Anita Carlizza, Marino Carnovali, Simona Sada, Anna Samaden, Chiara Casarsa, Filippo Mearelli, Giulia Pivetti, Roberto Catalini, Oriana Zingaretti, Medicina Vascolare, Stefania Cavazza, Benilde Cosmi, Caterina Cenci, Domenico Prisco, Elena Silvestri, Fabrizio Ceresa, Francesco Patanè, Antonio Ciampa, Valeria Siniscalchi, Tiziana Ciarambino, Giuseppe De Bartolomeo, Michele Clemente, Franco Conti, Laura Paiella, Maria D'Avino, Aldo D'Alessandro, Marisa Placentino, Vito Sollazzo, Armando D'Angelo, Silvana Viganò, Paolo De Campora, Raffaele Sangiuolo, Stefano De Franciscis, Raffaele Serra, Egidio De Gaudenzi, Fernando De Santis, Giovanni Carlo Piccinni, Italo D. De Tommaso, Letizia Di Francesco, Giovanni Maria Vincentelli, Rosario Di Maggio, Giorgia Saccullo, Sergio Siragusa, Pierpaolo Di Micco, Andrea Fontanella, Dario Di Michele, Giovanni Di Minno, Antonella Tufano, Marcello Di Nisio, Ettore Porreca, Francesca Donadio, Davide Imberti, Iolanda Enea, Fabio Fabbian, Roberto Manfredini, Marco Pala, Anna Falanga, Viola Milesi, Valerio Fiore, Elio Franco, Giorgio Giudice, Gabriele Frausini, Marina Rovinelli, Mariella Fuorlo, Raffaele Landolfi, Tiziana Morretti, Susanna Gamberini, Raffaella Salmi, Angelo Ghirarduzzi, Maria Rosaria Veropalumbo, Mauro Ghizzi, Carlo Pepe, Francesca Gianniello, Ida Martinelli, Diana Irina Iosub, Franco Piovella, Ercole Iozzi, Agostino Talerico, Micaela La Regina, Francesco Orlandini, Letizia Marconi, Antonio Palla, Rossella Marcucci, Daniela Poli, Riccardo Margheriti, Gianpaolo Sala, Alfonso Marra, Fausto Marrocco, Elisabetta Sara Montagna, Franco Silvestris, Simona Vallarelli, Lucio Mos, Valeria Rossetto, Francesco Mugno, Michelangelo Di Salvo, Cinzia Nitti, Milena Pennacchioni, Aldo Salvi, Oliviero Olivieri, Federica Tosi, Francesco Zorzi, Maicol Onesta, Valeria Pagliara, Sabina Villalta, Giancarlo Paolucci, Salvatore Severino, Francesca Pierri, Vitantonio Russo, Attilia Maria Pizzini, Roberto Quintavalla, Pasquale Rubino, Luigi Ria, Alessandro Schenone, Cosimo Strafino, Pietro Tropeano, Alfredo Vetrano, Nello Zanatta, Maria Dolores Adarraga Cansino, Juan Alonso Gutierrez, Francisco Arnaiz de las Revillas, Cristina Amado Fernández, Núria Calvo Mijares, Maria Ángeles Blanco-Molina, Maria Angelina Garcia, Dolores Joya Seijo, Rocío Aranda Blazquez, Juan Bosco López-Sáez, Eduardo Arellano Rodrigo, Jaume Villalta Blanch, Arola Armengou Arxe, Fernando García Bragado Dalmau, Aitor Ballaz Quincoces, Amaia García Loizaga, José Luis Beato Pérez, Pedro Bedate Díaz, Andrés Quezada Loaiza, Marc Cairols Castellote, Inma Cañas Alcántara, Meritxell Lluís Padierna, Marina Carrasco Expósito, Amparo Carrasco Mas, Fernando Cereto Castro, Rafael Castrodeza Sanz, Juan Ortiz de Saracho, Elena Cisneros de la Fuente, Cristina de Ancos Aracil, Justo Ruiz Ruiz, Maria Dolores de Daborenea González, Alfonso Fernández Iglesias, Javier de la Fuente Aguado, Lucia González González, Maria del Carmen Fernández-Capitán, Alicia Lorenzo Hernández, Jorge del Toro Cervera, Gloria Pérez Rus, Juan Luis Delgado Bregel, Florentino Díez Fernández, Elias Hernández Teresa Elias Hernández, Luis Jara Palomares, Ramón Ferri Bataler, José Antonio Nieto Rodríguez, José María García García, José Ramón González Porras, María Guil García, Elena Hernando López, Alejandra Roncero Lázaro, María Jesús Jaras, David Jiménez Castro, Rafael Jiménez Rodríguez Madridejos, José María Pedrajas Navas, Ramón Lecumberri, Nicolás Martínez, Genoveva Teresa López Castellanos, Luis Manzano Espinosa, Luciano López Jiménez, Olga Madridano Cobo, Carmen Mainez Saiz, Yolanda Romero Pizarro, Pablo Javier Marchena Yglesias, Mar Martín del Pozo, Leonardo Melibovsky, Emilia Solé Altarriba, Manuel Monreal Bosch, Rafael Monte Secades, José Maria Mora Luján, Antoni Riera Mestre, Pedro Moral Moral, José Antonio Todolí Parra, Aurora Moreno Flores, Juan Francisco Sánchez Muñoz-Torrero, Francisco José Muñoz Rodríguez, Manuel J Núñez Fernández, Estefanía Oncala Sibajas, Mercedes Vaquero de Sedas, Pedro Parra Caballero, Isaac Pons Martín del Campo, José Portillo Sánchez, Alberto Rivera Gallego, Iria Villaverde álvarez, Eva Maria Rodríguez Beltrán, Demetrio Sánchez Fuentes, Vanessa Roldán Schilling, Julio Sánchez álvarez, Gregorio Tiberio López, José Maria Suriñach Caralt, Raimundo Tirado Miranda, Esther Usandizaga de Antonio, Martin Banyai, Ulrich Frank, Reto Jörg Gian Reto Jörg, Christina Jeanneret, Daniel Staub, Sam Ackroyd, Gaurav Agarwal, Ben Mearns, Raza Alikhan, Allameddine Allameddine, Faris Al-Refaie, Christopher Arden, Antony Austin, Ameet Bakhai, Thomas Barton, Hayder Ewad, Richard Body, Jecko Thachil, Joseph Chacko, Deepak Chandra, Freda Charters, Alistair Church, Frances McGrane, John Clements, Piers Clifford, Dominic Cox, Matthew Crouch, Mark Crowther, Emyr Davies, Mark Davies, Sameh Dimitri, Anja Drebes, Simon Franklin, Jacob George, Nicola Irvine, Hagen Gerofke, Christopher Gibbs, Teik Goh, Sunil Gupta, Jon Holmes, Ewart Jackson-Voyzey, Nick Jones, Arun Kallat, Patrick Kerr, Patrick Kesteven, Tristan Lench, William Lester, Gillian Lowe, Martin Lewis, Terry McCormack, Andrew McCoye, Andrew Moriarty, Wendy Morris, Bethan Myers, Mekkali Narayanan, New Oo, Matthew Reed, Peter Rose, Khalid Saja, Muttuswamy Sivakumaran, Mamta Sohal, Gary Solomons, Sayed J. Sultanzadeh, Tamsin Venton, John Wakeling, Ceri Walby, Michael Waldron, Simon Watt, William Willcock, Azhar Zafar

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Venous thromboembolism (VTE) is a major health problem, with over one million events every year in Europe. However, there is a paucity of data on the current management in real life, including factors influencing treatment pathways, patient satisfaction, quality of life (QoL), and utilization of health care resources and the corresponding costs. The PREFER in VTE registry has been designed to address this and to understand medical care and needs as well as potential gaps for improvement. Methods/design: The PREFER in VTE registry was a prospective, observational, multicenter study conducted in seven European countries including Austria, France Germany, Italy, Spain, Switzerland, and the UK to assess the characteristics and the management of patients with VTE, the use of health care resources, and to provide data to estimate the costs for 12 months treatment following a first-time and/or recurrent VTE diagnosed in hospitals or specialized or primary care centers. In addition, existing anticoagulant treatment patterns, patient pathways, clinical outcomes, treatment satisfaction, and health related QoL were documented. The centers were chosen to reflect the care environment in which patients with VTE are managed in each of the participating countries. Patients were eligible to be enrolled into the registry if they were at least 18 years old, had a symptomatic, objectively confirmed first time or recurrent acute VTE defined as either distal or proximal deep vein thrombosis, pulmonary embolism or both. After the baseline visit at the time of the acute VTE event, further follow-up documentations occurred at 1, 3, 6 and 12 months. Follow-up data was collected by either routinely scheduled visits or by telephone calls. Results: Overall, 381 centers participated, which enrolled 3,545 patients during an observational period of 1 year. Conclusion: The PREFER in VTE registry will provide valuable insights into the characteristics of patients with VTE and their acute and mid-term management, as well as into drug utilization and the use of health care resources in acute first-time and/or recurrent VTE across Europe in clinical practice. Trial registration: Registered in DRKS register, ID number: DRKS00004795

Original languageEnglish
Article number41
JournalThrombosis Journal
Volume13
Issue number1
DOIs
Publication statusPublished - Oct 21 2015

Keywords

  • Anticoagulation
  • Novel Oral Anticoagulants
  • Prevention
  • Registry
  • Venous Thromboembolism
  • Vitamin K antagonists

ASJC Scopus subject areas

  • Hematology

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