The management of HCV infected pregnant women and their children European paediatric HCV network

Lucy Pembrey, Marie Louise Newell, Pier Angelo Tovo, A. Amoroso, E. Bevilaqua, F. Asensi-Botet, A. Pereda, V. Balossini, G. Bona, M. Zaffaroni, A. Bandelloni, A. Coscia, C. Fabris, S. Aime, C. Belloni, G. Bossi, B. Salati, C. Boucher, W. Buffolano, K. ButlerL. Cabero Roura, J. M Bertran Sanges, P. Cigna, L. M. Ciria, C. Servera Ginard, G. Claret Teruel, C. Fortuny, O. Coll, A. Corrias, R. Ledda, S. Floris, A. De Maria, J. Echeverria, G. Cilla, G. Faldella, M. Lanari, E. Tridapalli, V. Venturi, B. Fischler, A. B. Bohlin, S. Lindgren, G. Lindh, V. Giacomet, M. Merlo, C. Figini, P. Erba, A. Viganò, S. Hannam, G. Mieli-Vergani, A. Hatzakis, C. Inchley, H. O. Fjaerli, A. Maccabruni, M. Marcellini, M. R. Sartorelli, P. Martin Fontelos, A. Mazza, J. Y Q Mok, A. Mûr, M. Viñolas, D. M. Paternoster, P. Grella, S. Polywka, I. Quinti, A. M. Casadei, A. Rojahn, A. Berg, R. Rosso, S. Ferrando, D. Bassetti, J. Ruiz Contreras, A. Manzanares, A. Ruiz Extremera, F. Salvini, G. V. Zuccotti, T. Schmitz, I. Grosch-Wörner, C. Feiterna Sperling, T. Piening, A. Vegnente, R. Iorio, A. Versace, L. Lazier, E. Palomba, C. Gabiano, L. Balbo, A. Zanetti, E. Tanzi

Research output: Contribution to journalArticlepeer-review


Background/Aims: As evidence accumulates relating to mother-to-child (vertical) transmission of hepatitis C virus (HCV), it is timely to draw up guidelines for the clinical management of HCV infected pregnant women and their children. Methods: A review of evidence from the European Paediatric HCV Network (EPHN) prospective study of HCV infected women and their children and other published studies. Meeting of EPHN clinical experts to reach a consensus on recommendations for management. Each recommendation was graded according to the level of evidence. Results/conclusions: Although several risk factors for mother-to-child transmission have been identified, none are modifiable and there are currently no interventions available to prevent vertical transmission of HCV. Data on timing of loss of maternal antibodies and reliability of diagnostic tests inform the optimum follow-up schedule for confirmation or exclusion of infection in children born to HCV infected women. Based on the current evidence, routine antenatal screening for HCV should not be introduced and neither elective caesarean section nor avoidance of breastfeeding should be recommended to HCV infected women to prevent mother-to-child transmission of HCV. HCV/HIV co-infected women should follow existing HIV guidelines.

Original languageEnglish
Pages (from-to)515-525
Number of pages11
JournalJournal of Hepatology
Issue number3
Publication statusPublished - Sep 2005


  • Clinical management
  • Diagnosis
  • Follow-up
  • Hepatitis C
  • Mother-to-child transmission
  • Paediatric
  • Pregnancy

ASJC Scopus subject areas

  • Gastroenterology

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