The management of recurrent respiratory tract infections in children

Urs B. Schaad, Nicola Principi

Research output: Contribution to journalArticlepeer-review


Respiratory tract infections (RTIs) constitute a major healthcare burden in children throughout the world. They tend to be recurrent, often causing multiple episodes of illness within a single year. Immature immune system, the presence of genetic and environmental factors and exposure to pathogens make young children highly susceptible to RTIs. These infections are still treated with antibiotics but the rise in resistant bacterial strains has prompted investigation of novel preventative strategies. One such approach to prevent recurrent RTIs (RRTIs) is the immunostimulant OM-85 that is an extract of eight pathogenic bacteria which has proven safe and effective as prophylaxis of recurrent respiratory infections in children at risk. Increased awareness and use of preventative approaches, including OM-85, are likely to help avoid the complications and co-morbidities of RTIs; and have the potential to significantly reduce the burden of disease and bacterial resistance.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalEuropean Infectious Disease
Issue number2
Publication statusPublished - 2012


  • Bacterial infection
  • Immune response
  • Immunostimulant
  • Lung damage
  • OM-85
  • Recurrent respiratory tract infections
  • Virus

ASJC Scopus subject areas

  • Infectious Diseases


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