The manifold actions of endocannabinoids on female and male reproductive events

Monica Bari, Natalia Battista, Valentina Pirazzi, Mauro Maccarrone

Research output: Contribution to journalArticle

Abstract

Epidemiological studies have highlighted the ever growing use of illegal drugs among teenagers. The negative effects of marijuana (a Cannabis sativa extract) on reproductive health are poorly known among young people, although chronic exposure to delta-9-tetrahydrocannabinol, the main psychoactive constituent of marijuana, impairs human reproductive potential by disrupting menstrual cycle, suppressing oogenesis and impairing embryo implantation and development, in women, and by increasing ejaculation problems, reducing sperm count and motility, and generating loss of libido and impotence, in men. Endocannabinoids, their metabolic enzymes and target receptors form the so called "endocannabinoid system" and they have been demonstrated to respond to fertility signals. In addition, they interfere with hormones, cytokines and other signalling molecules in both female and male reproductive events. In this review, we shall summarize the current knowledge on the endocannabinoid system, and on the multifaceted roles played by endocannabinoids in reproduction along the evolutionary axis from invertebrates to mammals. Furthermore, we shall discuss the potential use of distinct elements of the endocannabinoid system for the diagnosis and/or treatment of human infertility.

Original languageEnglish
Pages (from-to)498-516
Number of pages19
JournalFrontiers in Bioscience
Volume16
Issue number2
DOIs
Publication statusPublished - Jan 1 2011

Keywords

  • Endocannabinoid System
  • Human Fertility
  • Oogenesis
  • Reproduction
  • Review
  • Spermatogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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