The many faces of blue nevus: A clinicopathologic study

Gerardo Ferrara, H. Peter Soyer, Josep Malvehy, Domenico Piccolo, Susana Puig, Juan Sopena, Iris Zalaudek, Giuseppe Argenziano

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Abstract

Background: In recent years, several histopathologic variants of blue nevus have been identified, whose clinical and dermoscopic correlates need further clarification. Methods: A comparative evaluation of histopathologic and dermoscopic features was carried out on 52 melanocytic proliferations belonging to the morphologic spectrum of blue nevus. Results: On dermoscopy, all lesions showed a homogeneous, structureless pigment pattern, with a curious variety of colors (blue, white-blue, black, brown, and polychromatic). Histopathologically, the majority of blue lesions were common blue nevi (11/19); the majority of white-blue lesions were 'hypochromic' (sclerotic, hypomelanotic, and amelanotic) blue nevi (17/22); all the black lesions were 'compound' blue nevi (2/2); the majority of brown lesions were combined blue nevi (3/4); the unusual polychromatic dermoscopic appearance was often associated with a histopathologic diagnosis of deep penetrating nevus (2/5). Conclusion: A dermoscopic-pathologic approach now allows us to identify 'blue' (common) blue nevi, 'white' (hypochromic) blue nevi, 'black' (compound) blue nevi, 'brown' (combined) blue nevi, and 'polychromatic' (deep penetrating) blue nevi. A better recognition of the many dermoscopic faces of blue nevi is expected to give a morphologic guideline for the clinical management of these lesions.

Original languageEnglish
Pages (from-to)543-551
Number of pages9
JournalJournal of Cutaneous Pathology
Volume34
Issue number7
DOIs
Publication statusPublished - Jul 2007

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Blue Nevus
Dermoscopy
Nevus

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Ferrara, G., Soyer, H. P., Malvehy, J., Piccolo, D., Puig, S., Sopena, J., ... Argenziano, G. (2007). The many faces of blue nevus: A clinicopathologic study. Journal of Cutaneous Pathology, 34(7), 543-551. https://doi.org/10.1111/j.1600-0560.2006.00650.x

The many faces of blue nevus : A clinicopathologic study. / Ferrara, Gerardo; Soyer, H. Peter; Malvehy, Josep; Piccolo, Domenico; Puig, Susana; Sopena, Juan; Zalaudek, Iris; Argenziano, Giuseppe.

In: Journal of Cutaneous Pathology, Vol. 34, No. 7, 07.2007, p. 543-551.

Research output: Contribution to journalArticle

Ferrara, G, Soyer, HP, Malvehy, J, Piccolo, D, Puig, S, Sopena, J, Zalaudek, I & Argenziano, G 2007, 'The many faces of blue nevus: A clinicopathologic study', Journal of Cutaneous Pathology, vol. 34, no. 7, pp. 543-551. https://doi.org/10.1111/j.1600-0560.2006.00650.x
Ferrara G, Soyer HP, Malvehy J, Piccolo D, Puig S, Sopena J et al. The many faces of blue nevus: A clinicopathologic study. Journal of Cutaneous Pathology. 2007 Jul;34(7):543-551. https://doi.org/10.1111/j.1600-0560.2006.00650.x
Ferrara, Gerardo ; Soyer, H. Peter ; Malvehy, Josep ; Piccolo, Domenico ; Puig, Susana ; Sopena, Juan ; Zalaudek, Iris ; Argenziano, Giuseppe. / The many faces of blue nevus : A clinicopathologic study. In: Journal of Cutaneous Pathology. 2007 ; Vol. 34, No. 7. pp. 543-551.
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