The measurement of global shortening as a new parameter to evaluate bone specimen response to uniaxial loading: Length change measurement for bone tissue specimens

Emanuele Rizzuto, Enrica Urciuoli, Barbara Peruzzi, Zaccaria Del Prete

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Mechanical load is nowadays considered one of the factor mainly affecting bone tissue properties, both as architecture and functionality. Mechanotransduction is the capability of cells to translate mechanical stresses into biochemical signals, and several studies performed on mouse models demonstrated that also bone cells show a high responsiveness to mechanical stimuli. To date, bone cells mechanotransduction is mainly investigated in animal models, by the use of organ cultures or directly in vivo, and the actual strains induced by the external loads are measured through the use of micro strain gauges placed on the tibia mid-diaphysis. With the aim of proposing a new parameter to come along with the measurement of the actual strains, we exploited the capability of tibial global shortening to return useful information. We employed an experimental system based on a dual mode actuator/transducer with an adequate force range and a high length resolution to retrieve the small shortening of the bone specimens subjected to uniaxially load. Preliminary results showed that the tibia global shortening has a linear relationship with the increasing load, in the range of force usually used in these studies. In addition, the tibia global shortening showed the capability of gathering the changes occurring in the bone tissue mechanical properties when subjecting the specimens to loading signals of different frequencies. When tested with load signals of a frequency equal or higher than 1 Hz, in fact, the bone specimens showed a more rigid behavior. At 9 N of load, for example, the average value of tibia global shortening measured at 0.1 Hz is, on average, 18 % higher than when measured at all the other tested frequencies.

Original languageEnglish
Title of host publication2016 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2016 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781467391726
DOIs
Publication statusPublished - Aug 4 2016
Event11th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2016 - Benevento, Italy
Duration: May 15 2016May 18 2016

Other

Other11th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2016
CountryItaly
CityBenevento
Period5/15/165/18/16

Fingerprint

tibia
bones
Bone
Tissue
cells
animal models
strain gages
Strain gages
organs
stimuli
mice
Transducers
Loads (forces)
transducers
Animals
Actuators
actuators
mechanical properties
Mechanical properties

Keywords

  • bio-mechanical properties
  • bone tissue
  • Mechanical loading
  • mechanotransduction
  • tibia global shortening

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Instrumentation

Cite this

Rizzuto, E., Urciuoli, E., Peruzzi, B., & Del Prete, Z. (2016). The measurement of global shortening as a new parameter to evaluate bone specimen response to uniaxial loading: Length change measurement for bone tissue specimens. In 2016 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2016 - Proceedings [7533726] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MeMeA.2016.7533726

The measurement of global shortening as a new parameter to evaluate bone specimen response to uniaxial loading : Length change measurement for bone tissue specimens. / Rizzuto, Emanuele; Urciuoli, Enrica; Peruzzi, Barbara; Del Prete, Zaccaria.

2016 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2016. 7533726.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rizzuto, E, Urciuoli, E, Peruzzi, B & Del Prete, Z 2016, The measurement of global shortening as a new parameter to evaluate bone specimen response to uniaxial loading: Length change measurement for bone tissue specimens. in 2016 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2016 - Proceedings., 7533726, Institute of Electrical and Electronics Engineers Inc., 11th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2016, Benevento, Italy, 5/15/16. https://doi.org/10.1109/MeMeA.2016.7533726
Rizzuto E, Urciuoli E, Peruzzi B, Del Prete Z. The measurement of global shortening as a new parameter to evaluate bone specimen response to uniaxial loading: Length change measurement for bone tissue specimens. In 2016 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2016. 7533726 https://doi.org/10.1109/MeMeA.2016.7533726
Rizzuto, Emanuele ; Urciuoli, Enrica ; Peruzzi, Barbara ; Del Prete, Zaccaria. / The measurement of global shortening as a new parameter to evaluate bone specimen response to uniaxial loading : Length change measurement for bone tissue specimens. 2016 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2016.
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