IL MECCANISMO D'AZIONE DEL CORYNEBACTERIUM PARVUM E SUE CONSEGUENZE PER TRATTAMENTI IMMUNOTERAPICI

Translated title of the contribution: The mechanism of action of Corynebacterium parvum and its implications in immunotherapeutic treatments

A. Vecchi, A. Tagliabue, A. Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

In an attempt to characterize the mechanism of action of C. parvum an analysis was performed of the changes in specific antitumoral immune effector mechanisms. C. parvum treated spleen displayed an increase in total cell number and in the percentage of macrophages; the percent of theta bearing lymphocytes was decreased whereas no modification in the percent of EA-rosette forming cells was observed. The efficiency of target cell lysis by immune splenocytes was unchanged, whereas there is a sizeable increase in the spleen capacity to mediate ADCC. On this basis a C. parvum treatment was combined with an ADCC-positive serum. While serum alone only prolongs the survival time and C. parvum has no effect, combination of the two treatments resulted in a clear synergism achieving cures in a significant percentage of hosts.

Translated title of the contributionThe mechanism of action of Corynebacterium parvum and its implications in immunotherapeutic treatments
Original languageItalian
Pages (from-to)242-244
Number of pages3
JournalFolia Allergologica et Immunologica Clinica
Volume24
Issue number2
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Immunology and Allergy

Fingerprint Dive into the research topics of 'The mechanism of action of Corynebacterium parvum and its implications in immunotherapeutic treatments'. Together they form a unique fingerprint.

Cite this