In an attempt to characterize the mechanism of action of C. parvum an analysis was performed of the changes in specific antitumoral immune effector mechanisms. C. parvum treated spleen displayed an increase in total cell number and in the percentage of macrophages; the percent of theta bearing lymphocytes was decreased whereas no modification in the percent of EA-rosette forming cells was observed. The efficiency of target cell lysis by immune splenocytes was unchanged, whereas there is a sizeable increase in the spleen capacity to mediate ADCC. On this basis a C. parvum treatment was combined with an ADCC-positive serum. While serum alone only prolongs the survival time and C. parvum has no effect, combination of the two treatments resulted in a clear synergism achieving cures in a significant percentage of hosts.
|Translated title of the contribution||The mechanism of action of Corynebacterium parvum and its implications in immunotherapeutic treatments|
|Number of pages||3|
|Journal||Folia Allergologica et Immunologica Clinica|
|Publication status||Published - 1977|
ASJC Scopus subject areas
- Immunology and Allergy