The mediating role of interpersonal conflict at work in the relationship between negative affectivity and biomarkers of stress

Damiano Girardi, Alessandra Falco, Alessandro De Carlo, Paula Benevene, Manola Comar, Enrico Tongiorgi, Giovanni Battista Bartolucci

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This study examined the association between interpersonal conflict at work (ICW) and serum levels of three possible biomarkers of stress, namely the pro-inflammatory cytokines Interleukin 1 beta (IL-1β), Interleukin 12 (IL-12), and Interleukin 17 (IL-17). Additionally, this study investigated the role of negative affectivity (NA) in the relationship between ICW and the pro-inflammatory cytokines. Data from 121 employees in an Italian healthcare organization were analyzed using structural equation modeling. Results showed that ICW was positively associated with IL-1β, IL-12, and IL-17, after controlling for the effect of gender. Moreover, ICW completely mediated the relationship between NA and the pro-inflammatory cytokines IL-1β, IL-12, and IL-17. This mediating effect was significant after controlling for the effect of gender. Overall, this study suggests that work-related stress may be associated with biomarkers of inflammation, and that negative affectivity may influence the stress process affecting the exposure to psychosocial stressors.

Original languageEnglish
Pages (from-to)922-931
Number of pages10
JournalJournal of Behavioral Medicine
Volume38
Issue number6
DOIs
Publication statusPublished - Jul 18 2015

Fingerprint

Biomarkers
Interleukin-17
Interleukin-12
Interleukin-1beta
Cytokines
Inflammation
Delivery of Health Care
Serum

Keywords

  • Interleukin 1 beta
  • Interleukin 12
  • Interleukin 17
  • Interpersonal conflict at work
  • Negative affectivity
  • Work-related stress

ASJC Scopus subject areas

  • Psychology(all)
  • Psychiatry and Mental health

Cite this

The mediating role of interpersonal conflict at work in the relationship between negative affectivity and biomarkers of stress. / Girardi, Damiano; Falco, Alessandra; De Carlo, Alessandro; Benevene, Paula; Comar, Manola; Tongiorgi, Enrico; Bartolucci, Giovanni Battista.

In: Journal of Behavioral Medicine, Vol. 38, No. 6, 18.07.2015, p. 922-931.

Research output: Contribution to journalArticle

Girardi, Damiano ; Falco, Alessandra ; De Carlo, Alessandro ; Benevene, Paula ; Comar, Manola ; Tongiorgi, Enrico ; Bartolucci, Giovanni Battista. / The mediating role of interpersonal conflict at work in the relationship between negative affectivity and biomarkers of stress. In: Journal of Behavioral Medicine. 2015 ; Vol. 38, No. 6. pp. 922-931.
@article{e54035eae40e4e2f8d77ad148785816d,
title = "The mediating role of interpersonal conflict at work in the relationship between negative affectivity and biomarkers of stress",
abstract = "This study examined the association between interpersonal conflict at work (ICW) and serum levels of three possible biomarkers of stress, namely the pro-inflammatory cytokines Interleukin 1 beta (IL-1β), Interleukin 12 (IL-12), and Interleukin 17 (IL-17). Additionally, this study investigated the role of negative affectivity (NA) in the relationship between ICW and the pro-inflammatory cytokines. Data from 121 employees in an Italian healthcare organization were analyzed using structural equation modeling. Results showed that ICW was positively associated with IL-1β, IL-12, and IL-17, after controlling for the effect of gender. Moreover, ICW completely mediated the relationship between NA and the pro-inflammatory cytokines IL-1β, IL-12, and IL-17. This mediating effect was significant after controlling for the effect of gender. Overall, this study suggests that work-related stress may be associated with biomarkers of inflammation, and that negative affectivity may influence the stress process affecting the exposure to psychosocial stressors.",
keywords = "Interleukin 1 beta, Interleukin 12, Interleukin 17, Interpersonal conflict at work, Negative affectivity, Work-related stress",
author = "Damiano Girardi and Alessandra Falco and {De Carlo}, Alessandro and Paula Benevene and Manola Comar and Enrico Tongiorgi and Bartolucci, {Giovanni Battista}",
year = "2015",
month = "7",
day = "18",
doi = "10.1007/s10865-015-9658-x",
language = "English",
volume = "38",
pages = "922--931",
journal = "Journal of Behavioral Medicine",
issn = "0160-7715",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - The mediating role of interpersonal conflict at work in the relationship between negative affectivity and biomarkers of stress

AU - Girardi, Damiano

AU - Falco, Alessandra

AU - De Carlo, Alessandro

AU - Benevene, Paula

AU - Comar, Manola

AU - Tongiorgi, Enrico

AU - Bartolucci, Giovanni Battista

PY - 2015/7/18

Y1 - 2015/7/18

N2 - This study examined the association between interpersonal conflict at work (ICW) and serum levels of three possible biomarkers of stress, namely the pro-inflammatory cytokines Interleukin 1 beta (IL-1β), Interleukin 12 (IL-12), and Interleukin 17 (IL-17). Additionally, this study investigated the role of negative affectivity (NA) in the relationship between ICW and the pro-inflammatory cytokines. Data from 121 employees in an Italian healthcare organization were analyzed using structural equation modeling. Results showed that ICW was positively associated with IL-1β, IL-12, and IL-17, after controlling for the effect of gender. Moreover, ICW completely mediated the relationship between NA and the pro-inflammatory cytokines IL-1β, IL-12, and IL-17. This mediating effect was significant after controlling for the effect of gender. Overall, this study suggests that work-related stress may be associated with biomarkers of inflammation, and that negative affectivity may influence the stress process affecting the exposure to psychosocial stressors.

AB - This study examined the association between interpersonal conflict at work (ICW) and serum levels of three possible biomarkers of stress, namely the pro-inflammatory cytokines Interleukin 1 beta (IL-1β), Interleukin 12 (IL-12), and Interleukin 17 (IL-17). Additionally, this study investigated the role of negative affectivity (NA) in the relationship between ICW and the pro-inflammatory cytokines. Data from 121 employees in an Italian healthcare organization were analyzed using structural equation modeling. Results showed that ICW was positively associated with IL-1β, IL-12, and IL-17, after controlling for the effect of gender. Moreover, ICW completely mediated the relationship between NA and the pro-inflammatory cytokines IL-1β, IL-12, and IL-17. This mediating effect was significant after controlling for the effect of gender. Overall, this study suggests that work-related stress may be associated with biomarkers of inflammation, and that negative affectivity may influence the stress process affecting the exposure to psychosocial stressors.

KW - Interleukin 1 beta

KW - Interleukin 12

KW - Interleukin 17

KW - Interpersonal conflict at work

KW - Negative affectivity

KW - Work-related stress

UR - http://www.scopus.com/inward/record.url?scp=84946476407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946476407&partnerID=8YFLogxK

U2 - 10.1007/s10865-015-9658-x

DO - 10.1007/s10865-015-9658-x

M3 - Article

VL - 38

SP - 922

EP - 931

JO - Journal of Behavioral Medicine

JF - Journal of Behavioral Medicine

SN - 0160-7715

IS - 6

ER -