The meniscus vascularization: the direct correlation with tissue composition for tissue engineering purposes

A. Giancamillo, L Mangiavini, I Tessaro, A. G. Marmotti, R. Scurati, G M Peretti

Research output: Contribution to journalArticlepeer-review

Abstract

Meniscal lesions still represent an unsolved problem in clinical practice. Like the articular cartilage, meniscus has a scarce healing potential. Thus, when this tissue is damaged, the joint biomechanics is completely altered, leading to the development and progression of premature osteoarthritis. Therefore, in the last years, several tissue-engineering strategies have been developed to regenerate the meniscus with debated results. The comprehension of complex processes underlying meniscus maturation and structure is essential for a correct approach for the generation of a biomimetic meniscal substitute. In this chapter, we will first review the morphology of the meniscus during growth, focusing on the unique pattern of vascularization, and then we will discuss the most common tissue engineering strategies for meniscus repair.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Volume30
Issue number4 Suppl 1
Publication statusPublished - Dec 23 2016

Keywords

  • Journal Article

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