The Met oncogene and basal-like breast cancer: another culprit to watch out for?

Stefania Gastaldi, Paolo M. Comoglio, Livio Trusolino

Research output: Contribution to journalArticle

Abstract

Recent findings suggest the involvement of the MET oncogene, encoding the tyrosine kinase receptor for hepatocyte growth factor, in the onset and progression of basal-like breast carcinoma. The expression profiles of basal-like tumors - but not those of other breast cancer subtypes - are enriched for gene sets that are coordinately over-represented in transcriptional signatures regulated by Met. Consistently, tissue microarray analyses have revealed that Met immunoreactivity is much higher in basal-like cases of human breast cancer than in other tumor types. Finally, mouse models expressing mutationally activated forms of Met develop a high incidence of mammary tumors, some of which exhibit basal characteristics. The present review summarizes current knowledge on the role and activity of Met in basal-like breast cancer, with a special emphasis on the correlation between this tumor subtype and the cellular hierarchy of the normal mammary gland.

Original languageEnglish
Pages (from-to)208
Number of pages1
JournalBreast Cancer Research
Volume12
Issue number4
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Medicine(all)

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