TY - JOUR
T1 - The MET oncogene as a therapeutical target in cancer invasive growth
AU - Luraghi, Paolo
AU - Schelter, Florian
AU - Krüger, Achim
AU - Boccaccio, Carla
PY - 2012
Y1 - 2012
N2 - The MET proto-oncogene, encoding the tyrosine kinase receptor for Hepatocyte Growth Factor (HGF) regulates invasive growth, a genetic program that associates control of cell proliferation with invasion of the extracellular matrix and protection from apoptosis. Physiologically, invasive growth takes place during embryonic development, and, in post-natal life, in wound healing and regeneration of several tissues. The MET oncogene is overexpressed and/or genetically mutated in many tumors, thereby sustaining pathological invasive growth, a prerequisite for metastasis. MET is the subject of intense research as a target for small molecule kinase inhibitors and, together with its ligand HGF, for inhibitory antibodies.The tight interplay of MET with the protease network has unveiled mechanisms to be exploited to achieve effective inhibition of invasive growth.
AB - The MET proto-oncogene, encoding the tyrosine kinase receptor for Hepatocyte Growth Factor (HGF) regulates invasive growth, a genetic program that associates control of cell proliferation with invasion of the extracellular matrix and protection from apoptosis. Physiologically, invasive growth takes place during embryonic development, and, in post-natal life, in wound healing and regeneration of several tissues. The MET oncogene is overexpressed and/or genetically mutated in many tumors, thereby sustaining pathological invasive growth, a prerequisite for metastasis. MET is the subject of intense research as a target for small molecule kinase inhibitors and, together with its ligand HGF, for inhibitory antibodies.The tight interplay of MET with the protease network has unveiled mechanisms to be exploited to achieve effective inhibition of invasive growth.
KW - Antibody
KW - Invasion
KW - MET oncogene
KW - Metastasis
KW - Microenvironment
KW - Proteases
KW - Small molecule kinase inhibitors
KW - Targeted therapy
UR - http://www.scopus.com/inward/record.url?scp=84867117229&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867117229&partnerID=8YFLogxK
U2 - 10.3389/fphar.2012.00164
DO - 10.3389/fphar.2012.00164
M3 - Article
C2 - 22973229
AN - SCOPUS:84867117229
VL - 3 SEP
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
SN - 1663-9812
M1 - Article 164
ER -