The MET oncogene in glioblastoma stem cells: Implications as a diagnostic marker and a therapeutic target

Carla Boccaccio, Paolo M. Comoglio

Research output: Contribution to journalArticle

Abstract

The MET oncogene, a crucial regulator of the genetic program known as "invasive growth" or "epithelial- mesenchymal transition," has recently emerged as a functional marker of glioblastoma stem cells. Here, we review findings that associate MET expression and activity with a specific, genetically defined glioblastoma stem cell subtype, and data showing howMET sustains the stemcell phenotype in glioblastoma and other tumors. Finally, we discuss issues related to identification of tumorigenic clones driven by MET in the context of genetically heterogeneous tumors and strategies aimed at eradicating cancer stem cells.

Original languageEnglish
Pages (from-to)3193-3199
Number of pages7
JournalCancer Research
Volume73
Issue number11
DOIs
Publication statusPublished - Jun 1 2013

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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